1 3 Dimethylamylamine - NutraPedia

Back to Table of Contents

1,3-Dimethylamylamine (DMAA) Overview

1) What conditions has it been studied for?

1,3-Dimethylamylamine has been studied for a variety of conditions, including as a performance enhancer for improving athletic performance, as a weight loss supplement, and for its potential to increase energy levels and concentration.

2) Does it work in treating those conditions?

There is limited and controversial evidence on the effectiveness of DMAA in treating these conditions. While some users report increased energy and improved focus, the scientific community has not reached a consensus, and regulatory agencies have raised concerns about its safety. Therefore, it is not officially recognized as a treatment for any condition.

3) What health benefits does it have?

Some purported health benefits of DMAA include increased energy levels, enhanced cognitive function, and weight loss due to its stimulant properties. However, these claims are not well-substantiated by rigorous scientific research, and the potential risks may outweigh any benefits.

4) Does it have any downsides?

Yes, DMAA has several potential downsides, including cardiovascular risks such as high blood pressure and heart attacks, neurological risks like seizures, psychiatric risks such as anxiety and mood changes, and the possibility of dependency or abuse. Due to these risks, it has been banned by various sports organizations and regulatory agencies, including the FDA.

5) Is it beneficial or harmful for any particular genetic variations?

There is no conclusive evidence linking DMAA's effects to specific genetic variations. The response to DMAA may vary among individuals due to genetic factors, but research on this subject is limited. It is important for individuals considering DMAA use to consult with healthcare providers and consider their own health risks and genetic predispositions.

1,3-Dimethylamylamine (DMAA) Summary

1,3-Dimethylamylamine (DMAA) is a substance that has been used in dietary supplements and is known for causing false-positive results in amphetamine testing. The Department of Defense's forensic laboratories found that 92.3% of urine samples with false-positive immunoassay results for amphetamines tested positive for DMAA when reanalyzed with liquid chromatography-tandem mass spectrometry (LC-MS-MS), at a concentration of about 6.0 mg/L.

DMAA, also known as methylhexamine, was originally patented in the 1950s as a nasal decongestant but has since been found in "party pills" and supplements claiming to contain geranium oil/extract, though the latter has been disputed. It has been the subject of regulatory scrutiny and banned in many countries due to safety concerns.

A reported case of toxicity involved a 21-year-old male who suffered a cerebral hemorrhage after ingesting DMAA-containing capsules. Furthermore, a study investigating the effects of DMAA on heart rate and blood pressure demonstrated that intake of this stimulant, particularly in combination with caffeine, could significantly increase blood pressure and rate pressure product (RPP) without affecting heart rate.

In summary, DMAA is a stimulant associated with false-positive drug tests, safety concerns, and cardiovascular effects, leading to its ban in various countries.

References:

Upload Whole Genome Sequencing (WGS) raw DNA data today and take a deep dive into your genome!

Or if you only have standard microarray data currently, upload raw DNA data to get started with your free DNA raw data analysis today!