Arachidonic Acid Overview

1) Conditions Studied

Arachidonic acid has been studied in relation to various health conditions, including:

• Inflammatory disorders
• Cardiovascular diseases
• Mental health conditions like depression
• Exercise-induced inflammation and muscle growth
• Asthma and other respiratory conditions

2) Efficacy in Treating Conditions

The effectiveness of arachidonic acid in treating these conditions is mixed and often depends on the context. For example:

• Its role as a precursor to pro-inflammatory compounds suggests that it could exacerbate inflammatory conditions.
• However, it may also contribute to muscle growth and repair post-exercise, which could be beneficial for athletes.

3) Health Benefits

Arachidonic acid has several potential health benefits:

• Essential for the growth and repair of skeletal muscle tissue.
• Important in brain development and function.
• Involved in the regulation of the immune system.

4) Downsides

Despite its benefits, there are potential downsides to arachidonic acid:

• May increase inflammation and contribute to inflammatory diseases.
• Could be associated with a higher risk of cardiovascular diseases due to its role in the production of thromboxanes.
• Excessive intake might negatively affect those with pre-existing conditions such as asthma.

5) Genetic Variations

The effects of arachidonic acid can be influenced by genetic variations:

• Individuals with genetic variations affecting fatty acid metabolism might see different effects from arachidonic acid consumption.
• Specific polymorphisms in the FADS1/FADS2 genes, which are involved in fatty acid metabolism, may influence how the body processes arachidonic acid.
• People with certain genetic variations may be more prone to the pro-inflammatory effects of arachidonic acid.

Summary of Research Studies on Arachidonic Acid

Effects of Dietary Arachidonic Acid: A study in Japan found that despite similar intake of arachidonic acid (ARA) across age groups, elderly people had lower blood levels of ARA. The consumption of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from fish may inhibit the incorporation of dietary ARA into blood phospholipids in the elderly.

Arachidonic Acid in Australian Diet: Research indicated that the amount of arachidonic acid (AA) in the Australian diet may have been overestimated in previous studies. New measurements suggest lower levels of AA than previously thought, with the average daily intake estimated at 130 mg for adult males and 96 mg for females.

Arachidonic Acid Content in American Foods: A study found that the actual AA content in most American foods, particularly in beef, turkey breast, and pork, was significantly higher than reported in Agriculture Handbook No. 8 (HB-8). Conversely, tuna had almost half the AA and n-3 fatty acid content compared to HB-8 figures.

Dietary Intake of Arachidonic Acid and its Influence: A study concluded that dietary intake of arachidonic acid influences its levels in the circulating pool in humans, but levels of eicosapentaenoic acid are not similarly affected by dietary restrictions.

Lean Beef Diet and Arachidonic Acid: A study involving 33 healthy volunteers consuming 500 grams of lean beef daily for four weeks indicated that such a diet increased the levels of various fatty acids in plasma phospholipids, including arachidonic acid.

Visible Meat Fat as a Source of Dietary AA: Research highlighted that visible meat fat is a significant source of dietary AA, especially for individuals consuming large amounts of pork or poultry fat.

Maternal Supplementation Impacting Breast Milk: Studies indicate that maternal supplementation with AA, especially when combined with DHA, can enhance the content of these fatty acids in breast milk, which may be beneficial for the neurodevelopment of the infant.

AA Supplementation and Cognitive Function: Supplementation with arachidonic acid may enhance cognitive function in healthy older adults, as evidenced by significant decreases in P300 latency and an increase in P300 amplitude in a study involving elderly Japanese men.

AA Enriched Diet and Muscle Growth: Research on muscle cells demonstrated that AA supplementation can enhance the growth of skeletal muscle cells through a mechanism that depends on the cyclooxygenase 2 (COX-2) enzyme and the production of specific prostaglandins.

Prostaglandin D2 and Allergic Inflammation: Studies have shown that PGD2 may contribute to allergic inflammation through both DP and CRTH2 receptors, with CRTH2 mediating changes in eosinophil shape, motion, and degranulation.

Arachidonic Acid and Exercise: Research suggests that exercise can lead to the release of arachidonic acid metabolites, such as prostaglandin E2, into the bloodstream, which may contribute to increased muscle blood flow during dynamic activities.

References:

1. Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women
2. Quantity and quality of dietary fat, carbohydrate, and fiber intake in the German EPIC cohorts
3. Dietary intakes and food sources of fatty acids for Belgian women, focused on n-6 and n-3 polyunsaturated fatty acids
4. The arachidonic acid content of the Australian diet is lower than previously estimated
5. Assessment of the arachidonic acid content in foods commonly consumed in the American diet
6. Reduced arachidonate in serum phospholipids and cholesteryl esters associated with vegetarian diets in humans
7. Diets rich in lean beef increase arachidonic acid and long-chain omega 3 polyunsaturated fatty acid levels in plasma phospholipids
8. Contribution of meat fat to dietary arachidonic acid
9. Comprehensive evaluation of fatty acids in foods. V. Unhydrogenated fats and oils
10. Comprehensive evaluation of fatty acids in foods. II. Beef products
11. THE EFFECT OF DOSE LEVEL OF ESSENTIAL FATTY ACIDS UPON FATTY ACID COMPOSITION OF THE RAT LIVER
12. The positional distribution of fatty acids in palm oil and lard influences their biologic effects in rats
13. Simple relationships exist between dietary linoleate and the n-6 fatty acids of human neutrophils and plasma
14. Increasing dietary linoleic acid does not increase tissue arachidonic acid content in adults consuming Western-type diets: a systematic review
15. Dietary arachidonate enhances tissue arachidonate levels and eicosanoid production in Syrian hamsters
16. Immediate and long range effects of the uptake of increased amounts of arachidonic acid
17. Anti-inflammatory effects of a low arachidonic acid diet and fish oil in patients with rheumatoid arthritis
18. Fatty acid amide hydrolase inhibitors--progress and potential
19. Enzymatic pathways that regulate endocannabinoid signaling in the nervous system
20. Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
21. Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels
22. Endocannabinoid hydrolases
23. Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease
24. Membrane arachidonic acid concentration correlates with age and induction of long-term potentiation in the dentate gyrus in the rat
25. Age-related changes in delta 6 and delta 5 desaturase activities in rat liver microsomes
26. Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor
27. Involvement of the arachidonic acid cascade in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal
28. Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases
29. Potassium regulates IL-1 beta processing via calcium-independent phospholipase A2
30. Stimulation of phospholipase A2 expression in rat cultured astrocytes by LPS, TNF alpha and IL-1 beta
31. Inhibition of phospholipase A(2) abrogates intracellular processing of NADPH-oxidase derived reactive oxygen species in human neutrophils
32. Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products
33. Aspirin as an antiplatelet drug
34. Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach
35. Prostaglandin G/H synthase isoenzyme 2 expression in fibroblasts: regulation by dexamethasone, mitogens, and oncogenes
36. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids
37. Inhibition of cyclooxygenase-2 activity enhances steroidogenesis and steroidogenic acute regulatory gene expression in MA-10 mouse Leydig cells
38. Serum and glucocorticoid regulation of gene transcription and expression of the prostaglandin H synthase-1 and prostaglandin H synthase-2 isozymes
39. Prostaglandin D synthase: structure and function
40. Antagonists of the prostaglandin D2 receptor CRTH2
41. Selective expression of a novel surface molecule by human Th2 cells in vivo
42. Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia
43. Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways
44. The bronchoconstrictor effect of inhaled prostaglandin D2 in normal and asthmatic men
45. 9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways
46. Plasma 9alpha,11beta-PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma
47. Prostaglandin E2 and pain--an update
48. Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor
49. MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation
50. Effects of AF3442 [N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro
51. Regulation of immune responses by prostaglandin E2
52. Prostaglandin and myokine involvement in the cyclooxygenase-inhibiting drug enhancement of skeletal muscle adaptations to resistance exercise in older adults
53. A critical role of the cAMP sensor Epac in switching protein kinase signalling in prostaglandin E2-induced potentiation of P2X3 receptor currents in inflamed rats
54. Prostanoids and inflammation: a new concept arising from receptor knockout mice
55. Possible cross-regulation of the E prostanoid receptors
56. Prostaglandin E receptors
57. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation
58. Mechanisms of platelet activation: thromboxane A2 as an amplifying signal for other agonists
59. Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
60. Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets
61. Supplementation of arachidonic acid-enriched oil increases arachidonic acid contents in plasma phospholipids, but does not increase their metabolites and clinical parameters in Japanese healthy elderly individuals: a randomized controlled study
62. Polyunsaturated fatty acids: do they have a role in the pathophysiology of autism?
63. Plasma fatty acid levels in autistic children
64. The fatty acid compositions of erythrocyte and plasma polar lipids in children with autism, developmental delay or typically developing controls and the effect of fish oil intake
65. Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: a double-blind, placebo-controlled, randomized trial
66. Phospholipase A2 activity is required for regeneration of sensory axons in cultured adult sciatic nerves
67. Involvement of phospholipase A2 in axonal regeneration of brain noradrenergic neurones
68. Arachidonic acid: toxic and trophic effects on cultured hippocampal neurons
69. n-6 polyunsaturated fatty acids increase the neurite length of PC12 cells and embryonic chick motoneurons
70. The production of arachidonic acid can account for calcium channel activation in the second messenger pathway underlying neurite outgrowth stimulated by NCAM, N-cadherin, and L1
71. Arachidonic acid preserves hippocampal neuron membrane fluidity in senescent rats
72. Arachidonic acid improves aged rats' spatial cognition
73. Synaptic plasticity preserved with arachidonic acid diet in aged rats
74. Arachidonic acid supplementation decreases P300 latency and increases P300 amplitude of event-related potentials in healthy elderly men
75. Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease
76. Celecoxib accelerates functional recovery after sciatic nerve crush in the rat
77. Arachidonic acid derivatives and their role in peripheral nerve degeneration and regeneration
78. Effects of dietary arachidonic acid supplementation on age-related changes in endothelium-dependent vascular responses
79. Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly individuals
80. Sources of eicosanoid precursor fatty acid pools in tissues
81. Dietary fatty acid profile influences the composition of skeletal muscle phospholipids in rats
82. Fatty acid profile of skeletal muscle phospholipids in trained and untrained young men
83. Training affects muscle phospholipid fatty acid composition in humans
84. Arachidonic acid supplementation enhances in vitro skeletal muscle cell growth via a COX-2-dependent pathway
85. Prostaglandin E2: from clinical applications to its potential role in bone- muscle crosstalk and myogenic differentiation
86. Prostaglandins and the control of muscle protein synthesis and degradation
87. The influence of changes in tension on protein synthesis and prostaglandin release in isolated rabbit muscles
88. Stretch-induced prostaglandins and protein turnover in cultured skeletal muscle
89. Effect of exercise on human arterial and regional venous plasma concentrations of prostaglandin E
90. Effect of prolonged exercise on plasma prostaglandin levels
91. In situ microdialysis of intramuscular prostaglandin and thromboxane in contracting skeletal muscle in humans
92. Skeletal muscle growth is stimulated by intermittent stretch-relaxation in tissue culture
93. Arachidonic acid supplementation enhances synthesis of eicosanoids without suppressing immune functions in young healthy men
94. Effects of arachidonic acid supplementation on training adaptations in resistance-trained males
95. Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis
96. Skeletal muscle PGF(2)(alpha) and PGE(2) in response to eccentric resistance exercise: influence of ibuprofen acetaminophen
97. Ameliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cells
98. Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent
99. Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells
100. Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites
101. Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation
102. Key role for ceramides in mediating insulin resistance in human muscle cells
103. A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
104. Vasodilatory mechanisms in contracting skeletal muscle
105. Effects of dynamic exercise on plasma arachidonic acid epoxides and diols in human volunteers
106. Effects of physical conditioning on lipids and arachidonic acid metabolites in untrained boys: a longitudinal study
107. Prostaglandin F2α: a bone remodeling mediator
108. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP
109. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
110. Expression and regulation of lipocalin-type prostaglandin d synthase in rat testis and epididymis
111. Influence of androgens on gene expression in the BALB/c mouse submandibular gland
112. Prostaglandins and thromboxanes
113. Prostaglandin-induced hair growth
114. Selective inhibition by minoxidil of prostacyclin production by cells in culture
115. Dietary arachidonic acid dose-dependently increases the arachidonic acid concentration in human milk
116. Human milk arachidonic acid and docosahexaenoic acid contents increase following supplementation during pregnancy and lactation
117. Effect of supplementation of arachidonic acid (AA) or a combination of AA plus docosahexaenoic acid on breastmilk fatty acid composition
118. Polyunsaturated fatty acid supply with human milk
119. Estimated biological variation of the mature human milk fatty acid composition
120. High contents of both docosahexaenoic and arachidonic acids in milk of women consuming fish from lake Kitangiri (Tanzania): targets for infant formulae close to our ancient diet?

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