Bulbine Natalensis - NutraPedia

Back to Table of Contents

Bulbine Natalensis Overview

1) Studied Conditions

Bulbine Natalensis has been studied for various conditions including:

Testosterone boosting effects
Libido enhancement
Physical performance improvement
Anti-diabetic effects
Wound healing properties

2) Efficacy in Treating Conditions

Research on Bulbine Natalensis is limited and results are mixed. Some animal studies suggest it may increase testosterone and enhance libido, but there is insufficient evidence to confirm these effects in humans. Its efficacy in improving physical performance and anti-diabetic effects is also unclear due to limited studies.

3) Health Benefits

Potential health benefits of Bulbine Natalensis based on preliminary studies may include:

Possible increase in testosterone levels
May enhance sexual performance and libido
Could aid in muscle growth and recovery
Anti-inflammatory and analgesic effects observed in some studies

4) Downsides

While Bulbine Natalensis may offer some health benefits, it also has potential downsides, such as:

Limited human clinical trials, with most studies conducted on animals
Potential hepatotoxicity, as some studies suggest it may harm the liver
May cause gastrointestinal disturbances
Long-term safety profile is not well-established

5) Impact on Genetic Variations

There is currently no established evidence linking Bulbine Natalensis to beneficial or harmful effects on specific genetic variations. Genetic factors can influence an individual's response to supplements and herbs, but more research is needed to determine the interactions between Bulbine Natalensis and genetic profiles.

Research Summary on Bulbine Natalensis

Anabolic and Androgenic Effects in Male Rats

A study conducted on male Wistar rats investigated the effects of Bulbine natalensis stem extract on male reproductive health. The research showed that the extract at doses of 25, 50, and 100 mg/kg body weight increased the testicular-body weight ratio and improved various biochemical markers in the testes. The most notable anabolic and androgenic effects were observed with the 50 mg/kg dose. Additionally, testosterone levels were elevated in the testicular tissue and serum, with delayed effects at the 100 mg/kg dosage.

Wound Healing Properties

Another study validated the traditional use of Bulbine natalensis for wound treatment. The application of leaf gels from the plant on domestic pig wounds resulted in faster wound contraction, increased tensile strength, and higher collagen, protein, and DNA content compared to untreated wounds. Both Bulbine natalensis and Bulbine frutescens improved wound healing, indicating their potential for developing topical treatments.

Sexual Behavior Enhancement in Male Rats

The aqueous extract from the stem of Bulbine natalensis was found to significantly improve sexual behavior in male rats at doses of 25 and 50 mg/kg body weight. Enhanced sexual performance, increased testosterone levels, and improved erectile function were observed, while a 100 mg/kg dose had adverse effects.

Effects on Blood Parameters and Lipid Profiles

The extract of Bulbine natalensis affected white blood cell counts and altered serum lipid profiles in male Wistar rats, leading to potential systemic toxicity and increased risk of atherosclerosis, particularly with repeated consumption over two weeks.

Impact on Reproductive Functions and Safety During Pregnancy

Low doses (25 and 50 mg/kg) of Bulbine natalensis stem extract enhanced reproductive success and hormone levels in male rats and were considered safe for female rats during early pregnancy. However, the 100 mg/kg dose may negatively affect reproductive functions in both sexes.

Liver and Kidney Function Assessment

The stem extract of Bulbine natalensis showed selective toxicity, potentially impacting liver and kidney functions negatively, as indicated by altered enzyme levels and histological changes in the organs of male Wistar rats. Caution is advised for oral use.

References:

Upload Whole Genome Sequencing (WGS) raw DNA data today and take a deep dive into your genome!

Or if you only have standard microarray data currently, upload raw DNA data to get started with your free DNA raw data analysis today!