Calcium D Glucarate - NutraPedia

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Calcium D Glucarate: Overview

1) Studied Conditions

Calcium D Glucarate has been studied for its potential effects in conditions such as:

Hormone-dependent cancers like breast, prostate, and colon cancers
High cholesterol levels
Liver detoxification and health

2) Efficacy in Treating Conditions

While some studies suggest potential benefits, the evidence is not conclusive for the treatment of the conditions listed above. More research is needed to establish its effectiveness.

3) Health Benefits

Reported health benefits of Calcium D Glucarate include:

Helping in the detoxification process
Potentially lowering the risk of certain types of cancer
May aid in reducing high cholesterol levels

4) Downsides

Known downsides of Calcium D Glucarate are generally few but may include:

Mild gastrointestinal discomfort in some individuals
Possible interactions with medications, necessitating consultation with a healthcare provider before use

5) Genetic Variations Impact

There is insufficient evidence to determine if Calcium D Glucarate is specifically beneficial or harmful for certain genetic variations. Personal genetics can influence how one metabolizes various compounds, but the relationship with Calcium D Glucarate requires more research.

Calcium D Glucarate: A Summary

Calcium-D-glucarate is a calcium salt of D-glucaric acid found in mammals and certain fruits and vegetables. It's particularly abundant in oranges, apples, grapefruits, and cruciferous vegetables. Supplementation with calcium-D-glucarate is known to inhibit beta-glucuronidase, an enzyme associated with an increased risk of hormone-related cancers such as breast, prostate, and colon cancer. Further, it can help regulate estrogen metabolism and lower lipid levels.

Research has shown that D-glucaric acid biosynthesis from D-glucuronic acid in mammals involves iron salts and hydrogen peroxide, with free-radical scavengers strongly inhibiting it. An intermediate, D-glucaro-1,5-lactone, is created during this process and is a powerful inhibitor of beta-D-glucuronidase. This inhibition is also observed when microsomal preparations with NADPH produce D-glucaric acid.

Calcium glucarate's role in the bloodstream has been studied for its impact on beta-glucuronidase. A single dose significantly reduced the enzyme's activity in serum and liver, and long-term dietary intake also led to a decrease in the enzyme's activity, with variations throughout the day. A diet supplemented with calcium glucarate reduced beta-glucuronidase activity in intestinal bacteria considerably.

The potential of D-glucaric acid and its derivatives for cancer prevention has been investigated. These compounds inhibit beta-glucuronidase and affect steroidogenesis and hormonal levels, contributing to cancer prevention or treatment. The formation of D-glucaro-1,4-lactone from D-glucaric acid derivatives is crucial for these anticancer effects.

Further studies have confirmed the chemopreventive properties of calcium D-glucarate, illustrating its ability to inhibit tumor promotion enzymes, reduce tumor development in mammary glands, alter the body's hormonal environment, and synergize with other compounds against mammary tumors.

Additional research has explored the role of enzymes in bilirubin metabolism, the inhibitory effects of D-glucaro-1,4-lactone on gallstone formation, the UGT enzymes' detoxification of tobacco carcinogens, and benzo[a]pyrene metabolism in hamster embryo cells. The findings have implications for cancer risk and potential dietary interventions.

The studies have also shed light on the biotransformation of harmful substances in marine organisms, the development of methods to measure D-glucaric acid in human urine, and the variability in liver enzymatic activity that affects testosterone bioavailability.

An investigation into the impact of dietary teas on testosterone glucuronidation revealed that compounds in green and white tea could inhibit the process, potentially affecting sports doping detection. Other studies demonstrated the anticancer potential of glucarate in reducing DNA synthesis in mammary glands and suppressing tumor growth through apoptotic pathways.

Research has highlighted the potential of phytochemicals in cancer prevention, the impact of genotypes on androgen receptor activity, and the synergistic effects of compounds like resveratrol and D-glucaro-1,4-lactone on platelet aggregation and oxidative stress.

Finally, studies have emphasized the effectiveness of dietary anticarcinogens such as D-glucaro-1,4-lactone and calcium glucarate in reducing the induction of oncofetal protein markers and the subsequent development of tumors in rodents exposed to chemical carcinogens.

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