Coleus Forskohlii: An Overview

1) Conditions Studied

Coleus Forskohlii, a traditional Ayurvedic herb, has been studied for several conditions including:

• Asthma
• High blood pressure
• Obesity
• Heart failure
• Glaucoma

2) Efficacy in Treating Conditions

While some studies suggest potential benefits of Coleus Forskohlii in treating these conditions, the evidence is not conclusive:

• Asthma: Some evidence suggests improvement in asthma symptoms.
• High Blood Pressure: Forskolin, the active compound, may lower blood pressure in some individuals.
• Obesity: Limited studies indicate it might help in weight management but more research is needed.
• Heart Failure: There is some early evidence of potential benefits, but it's not substantial enough to recommend it as a treatment.
• Glaucoma: Early research shows potential for intraocular pressure reduction, but not enough to replace conventional treatments.

3) Health Benefits

Coleus Forskohlii is believed to offer several health benefits:

• May increase levels of cyclic AMP (cAMP), which is involved in various biochemical processes.
• Could potentially support heart health and weight loss as part of a healthy lifestyle.
• May improve airways in asthma by relaxing the smooth muscle tissue.

4) Downsides

Despite potential health benefits, Coleus Forskohlii may have downsides:

• May cause side effects such as headaches, low blood pressure, and increased heart rate.
• Interactions with certain medications can occur, necessitating caution especially in patients with cardiovascular diseases.
• Pregnant and breastfeeding women should avoid it due to lack of safety data.

5) Genetic Variations and Effects

As of the current knowledge, there is no substantial evidence to suggest that Coleus Forskohlii is particularly beneficial or harmful for specific genetic variations. However, individual responses to supplements can vary based on genetics, which can influence efficacy and risk of side effects:

• Genetic variations affecting blood pressure regulation may alter an individual's response to Coleus Forskohlii.
• People with specific genetic markers associated with obesity might experience different weight loss results.
• As with any supplement, genetic factors can influence how well the body metabolizes and reacts to Coleus Forskohlii.

Note: The information provided here is based on the current research available at the time of the knowledge cutoff. Always consult with a healthcare provider before starting any new supplement regimen.

Summary on Coleus Forskohlii

Forskolin's Antimetastatic and Anti-HIV Effects

Forskolin, derived from the Coleus forskohlii plant, has been studied for its antimetastatic properties, significantly reducing melanoma-induced platelet aggregation and lung tumor colonization in mice. Additionally, forskolin and its derivatives have demonstrated inhibitory effects on HIV-1 NL4-3, marking the first report of anti-HIV activity for Coleus forskohlii.

Chemical Composition of Coleus Forskohlii

Research has identified various compounds in Coleus forskohlii, including new diterpenoids, forskolin derivatives, and previously undiscovered compounds in the Coleus genus. These findings expand knowledge of the plant's chemical makeup and potential medicinal properties.

Therapeutic Potential of Forskolin

Forskolin, isolated from Plectranthus barbatus, serves as a direct activator of adenylyl cyclase, increasing cAMP levels in cells. This has contributed to its use in investigating the role of cAMP in physiological and pathological processes, offering potential therapeutic applications for various conditions.

Impact on Adenylate Cyclase Isoforms

Advancements in understanding adenylate cyclase isoforms have led to modified forskolin compounds with improved selectivity, hinting at the possibility of developing new drugs that target specific AC isoforms, enhancing the regulation of neurohormonal signals.

Forskolin in Weight Management and Glaucoma Treatment

Studies indicate that forskolin supplementation may assist in preventing weight gain without significant side effects and contribute to intraocular pressure control in glaucoma patients when combined with other treatments.

Coleus Forskohlii's Influence on Drug Metabolism

Coleus forskohlii extract has been found to affect liver enzymes responsible for drug metabolism in mice, suggesting potential interactions with medications and the importance of evaluating its safety in drug combinations.

References:

1. Forskolin: a potential antimetastatic agent
2. [Studies on the chemical constituents of Coleus forskohlii]
3. Anti-HIV diterpenes from Coleus forskohlii
4. Three new diterpenoids from Coleus forskohlii Briq
5. Two new diterpenoids from Coleus forskohlii
6. Forskolin and derivatives as tools for studying the role of cAMP
7. Diterpenes from Coleus forskohlii (WILLD.) BRIQ. (Labiatae)
8. Two minor diterpene glycosides and an eudesman sesquiterpene from Coleus forskohlii
9. Function of Plectranthus barbatus herbal tea as neuronal acetylcholinesterase inhibitor
10. [Studies on the chemical constituents in root of Coleus forskohlii]
11. Comparative effects of forskolin and isoproterenol on the cyclic AMP content of human adipocytes
12. Isoform-specific regulation of adenylyl cyclase: a potential target in future pharmacotherapy
13. Regulation and role of adenylyl cyclase isoforms
14. Forskolin as an activator of cyclic AMP accumulation and lipolysis in rat adipocytes
15. Alpha-2 adrenergic activation inhibits forskolin-stimulated adenylate cyclase activity and lipolysis in human adipocytes
16. Skeletal muscle NAMPT is induced by exercise in humans
17. Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohlii
18. Intestinal permeability of forskolin by in situ single pass perfusion in rats
19. Caffeine inhibits forskolin-stimulated cyclic AMP accumulation in rat brain
20. Is adenosine involved in inhibition of forskolin-stimulated cyclic AMP accumulation by caffeine in rat brain?
21. Forskolin stimulation of cyclic AMP accumulation in rat brain cortex slices is markedly enhanced by endogenous adenosine
22. Effect of adenosine receptor agonists and other compounds on cyclic AMP accumulation in forskolin-treated hippocampal slices
23. A comparison of A2 adenosine receptor-induced cyclic AMP generation in cerebral cortex and relaxation of pre-contracted aorta
24. A1 adenosine receptor inhibition of cyclic AMP formation and radioligand binding in the guinea-pig cerebral cortex
25. Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women
26. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men
27. Clinical efficacy of Coleus forskohlii (Willd.) Briq. (Makandi) in hypertension of geriatric population
28. Alterations in adipocyte adenylate cyclase activity in morbidly obese and formerly morbidly obese humans
29. Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase
30. Contribution of the extracellular cAMP-adenosine pathway to dual coupling of β2-adrenoceptors to Gs and Gi proteins in mouse skeletal muscle
31. Forskolin attenuates the action of insulin on the Akt-mTOR pathway in human skeletal muscle
32. Insulin sensitivity and inhibition by forskolin, dipyridamole and pentobarbital of glucose transport in three L6 muscle cell lines
33. Cyclic AMP-induced transcriptional repression of the insulin-responsive glucose transporter (GLUT4) gene: identification of a promoter region required for down-regulation of transcription
34. Transcription factor NF1 mediates repression of the GLUT4 promoter by cyclic-AMP
35. Cyclic adenosine 3',5'-monophosphate regulates GLUT4 and GLUT1 glucose transporter expression and stimulates transcriptional activity of the GLUT1 promoter in muscle cells
36. Remodeling lipid metabolism and improving insulin responsiveness in human primary myotubes
37. Involvement of PPAR gamma co-activator-1, nuclear respiratory factors 1 and 2, and PPAR alpha in the adaptive response to endurance exercise
38. Invited Review: contractile activity-induced mitochondrial biogenesis in skeletal muscle
39. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1
40. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis
41. Intracavernosal forskolin: role in management of vasculogenic impotence resistant to standard 3-agent pharmacotherapy
42. Forskolin lowers intraocular pressure in rabbits, monkeys, and man
43. Aqueous flow in human eyes is reduced by forskolin, a potent adenylate cyclase activator
44. Natural therapies for ocular disorders, part two: cataracts and glaucoma
45. Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activity
46. Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture
47. Brain-derived neurotrophic factor prevents axotomized retinal ganglion cell death through MAPK and PI3K signaling pathways
48. Brain-derived neurotrophic factor reduces TrkB protein and mRNA in the normal retina and following optic nerve crush in adult rats
49. Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo
50. Oral administration of an association of forskolin, rutin and vitamins B1 and B2 potentiates the hypotonising effects of pharmacological treatments in POAG patients
51. Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy
52. Coleus forskohlii extract induces hepatic cytochrome P450 enzymes in mice
53. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway
54. In vitro acute and prolonged effects of melatonin on purified rat Leydig cell steroidogenesis and adenosine 3',5'-monophosphate production
55. Cell biology of Leydig cells in the testis
56. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones
57. Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis
58. Forskolin, an activator of adenylate cyclase, stimulates pancreatic insulin, glucagon, and somatostatin release in the dog: studies in vitro
59. Effect of forskolin on beta-adrenergic hyporesponsiveness in skin
60. Desensitization in rat parotid to beta-adrenergic agonists and counteracting effects of forskolin are conserved in membrane and detergent-solubilized adenylate cyclase catalyst activity
61. Lipolysis and lipid mobilization in human adipose tissue
62. Role of phospholamban in the modulation of arterial Ca(2+) sparks and Ca(2+)-activated K(+) channels by cAMP
63. cAMP/PKA-dependent increases in Ca Sparks, oscillations and SR Ca stores in retinal arteriolar myocytes after exposure to vasopressin
64. Alpha 2-adrenergic receptor-mediated sensitization of forskolin-stimulated cyclic AMP production
65. Characterization and possible mechanisms of alpha 2-adrenergic receptor-mediated sensitization of forskolin-stimulated cyclic AMP production in HT29 cells
66. Coleus forskohlii. Monograph
67. Forskolin refractoriness. Exposure to the diterpene alters guanine nucleotide-dependent adenylate cyclase and calcium-uptake activity of cells cultured from the rat aorta
68. Forskolin-stimulated cyclic AMP accumulation mediates protein synthesis-dependent refractoriness in C6-2B rat glioma cells

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