Creatinol O Phosphate Overview

1) Studied Conditions

Creatinol O Phosphate has been studied for various conditions, particularly those related to heart health and exercise performance. These include cardiac insufficiency, ischemic heart disease, and as a potential supplement for improving muscle strength and endurance during physical activity.

2) Effectiveness in Treating Conditions

The efficacy of Creatinol O Phosphate for treating heart conditions has shown some promise in early studies. However, its role in improving exercise performance is less clear, with limited evidence supporting its use. More research is needed to ascertain its effectiveness conclusively.

3) Health Benefits

• May improve the contractility of the heart muscle.
• Potential to protect the heart during periods of low oxygen supply (ischemia).
• Could offer some benefit in enhancing muscle strength and endurance, although evidence is mixed.

4) Potential Downsides

While Creatinol O Phosphate is generally considered safe when used appropriately, potential downsides may include gastrointestinal disturbances, and the lack of extensive research means there could be unknown long-term effects. It is always advisable to consult with a healthcare provider before starting any new supplement regimen.

5) Impact on Genetic Variations

As of the current knowledge cutoff, there is limited information on how Creatinol O Phosphate interacts with specific genetic variations. Personal genetics can influence how one responds to supplements, but without concrete research, it is difficult to say whether it is particularly beneficial or harmful for any specific genetic variations.

Creatinol O-Phosphate (COP) Research Summary

Cardiac Recovery and Protection

Studies demonstrate that Creatinol O-Phosphate (COP) enhances heart muscle contractions and improves recovery post-hypoxia and ischemia. It exhibits a positive inotropic effect along with a negative chronotropic effect, aiding in better recovery after oxygen and blood flow are restored. COP's beneficial effects extend to hearts under cardioplegic protection, suggesting a potential role in heart surgery scenarios.

Pharmacological and Toxicological Profile

COP shows a favorable pharmacological profile with anti-ischemic and anti-arrhythmic properties. It is well-absorbed intramuscularly, distributes in critical organs, and is dephosphorylated and excreted via the kidneys and liver. Toxicological studies confirm that COP is safe and well-tolerated, with a wide therapeutic index.

Prevention of Isoprenaline-Induced Cardiac Damage

Pre-treatment with COP significantly reduces heart damage and ionic imbalances induced by isoprenaline in rats. Moreover, it shows promise in reducing the severity of heart lesions when administered before isoprenaline, indicating a protective effect against myocardial infarction.

Antiarrhythmic Effects

COP delays the onset of experimentally induced arrhythmias and counteracts ventricular fibrillation. Clinical trials have shown COP to significantly reduce ventricular premature beats in patients with ischemic heart disease without side effects, supporting its potential use in antiarrhythmic therapy.

Impact on Serum Enzymes and Electrophysiology

In patients with acute myocardial infarction, COP treatment resulted in a notable decrease in serum enzymes associated with cell damage. Additionally, COP does not alter electrophysiological parameters in humans, indicating its safety for use in patients with pre-existing heart conditions.

Acute Tolerance in Healthy Humans

A study on healthy volunteers revealed that COP is tolerated well at various dosages. No significant changes were observed in arterial pressure, heart rate, ECG patterns, or blood analysis, aside from an increase in blood phosphate at higher doses.

References:

1. Action of creatinol-O-phosphate on the contractility changes evoked by hypoxia and ischemia in rat isolated heart
2. Pharmacological and toxicological properties of creatinol O-phosphate. A review
3. The prevention by creatinol O-phosphate of myocardial lesions evoked by isoprenaline
4. Protective effect of creatinol O-phosphate (COP) on some experimental arrhythmias in vitro and in vivo
5. An analysis of the reduction by creatinol O-phosphate of the myocardial lesions evoked by isoprenaline in the rat
6. Effects of creatinol O-phosphate on serum enzymes in acute myocardial infarction
7. Activity of creatinol O-phosphate on persistent ventricular premature beats in ischemic heart disease. Double blind clinical trial
8. Antiarrhythmic effectiveness of creatinol O-phosphate in man
9. Preliminary report on electrophysiological effectiveness of creatinol O-phosphate (COP) in human subjects
10. Acute clinical tolerance of creatinol O-phosphate

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