D Ribose - NutraPedia

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D-Ribose Overview

1. Studied Conditions

D-Ribose has been studied for several conditions, including:

  • Chronic fatigue syndrome (CFS)
  • Fibromyalgia
  • Coronary artery disease
  • Congestive heart failure
  • Myoadenylate deaminase deficiency

2. Efficacy in Treating Conditions

Research on the effectiveness of D-Ribose for treating these conditions is mixed:

  • Some studies suggest potential benefits for individuals with coronary artery disease and chronic heart conditions by improving energy metabolism in heart cells.
  • However, evidence for its effectiveness in treating CFS, fibromyalgia, and other conditions is limited and inconclusive.

3. Health Benefits

Reported health benefits of D-Ribose may include:

  • Improved cardiac energy metabolism and function
  • Potential reduction of symptoms related to certain metabolic disorders
  • Enhancement of physical performance and recovery in athletes

4. Downsides

While D-Ribose is generally considered safe for most individuals, there are potential downsides:

  • Gastrointestinal discomfort, such as diarrhea, if consumed in large amounts.
  • May lead to hypoglycemia in some individuals, especially those with diabetes or hypoglycemia.
  • Long-term effects and safety have not been extensively studied.

5. Genetic Variations

There is limited research on the effects of D-Ribose with respect to specific genetic variations. However, individuals with:

  • Myoadenylate deaminase deficiency might experience symptom relief from supplementing with D-Ribose.
  • Other genetic conditions that affect sugar metabolism should consult with a healthcare provider before using D-Ribose.

As with any supplement, it is important to consider individual health circumstances and consult with a healthcare professional before starting any new regimen.

Research Summary on D-Ribose

Introduction to D-Ribose

D-Ribose is a naturally occurring sugar that plays a crucial role in the synthesis of adenosine triphosphate (ATP), an essential molecule for energy transfer in cells. It has gained attention for its potential benefits in improving cardiac energy metabolism, especially under conditions like ischemia, where ATP synthesis is compromised.

Impact on Skeletal Muscle Fibers

Studies have shown that the synthesis and salvage rates of adenine nucleotides (AdNs) in skeletal muscle fibers vary by fiber type and are closely linked to the muscle's oxidative characteristics. The availability of D-Ribose significantly enhances the salvage rates of AdNs, indicating a preference for the salvage pathway over de novo synthesis for maintaining the AdN pool in muscles.

Benefits for Cardiac Function

D-Ribose supplementation has been associated with improved tolerance to myocardial ischemia, enhanced detection of hibernating myocardium, and improved cardiac function during the diastolic phase in patients with chronic coronary artery disease and congestive heart failure (CHF). It may also aid in ATP resynthesis, thus potentially improving heart function and quality of life for patients with these conditions.

Effects on Exercise Performance and Recovery

Research indicates that oral ribose supplementation can improve the rate of ATP resynthesis following intense exercise, aiding in quicker recovery of adenine nucleotides. However, the decrease in muscle ATP following intense training did not significantly limit performance in high-intensity exercise.

Enhancing Exercise Capacity in Heart Failure

D-Ribose supplementation was found to enhance exercise capacity in patients with advanced heart failure by improving breathing parameters during exercise and reducing the symptoms of heart failure.

Adjunctive Treatment for Myocardial Ischemia

The administration of D-Ribose has shown potential as an adjunctive treatment for myocardial ischemia by enhancing the heart's tolerance to ischemic conditions in patients with severe coronary artery disease.

Conclusions

Overall, D-Ribose appears to offer significant benefits in conditions related to impaired energy metabolism, such as cardiac diseases, muscle recovery after intense exercise, and certain muscle-related disorders. While further research is needed, the current evidence suggests that D-Ribose can be a valuable supplement for improving energy metabolism and function in various tissues.

References:


  1. De novo synthesis of adenine nucleotides in different skeletal muscle fiber types
  2. Purine salvage to adenine nucleotides in different skeletal muscle fiber types
  3. D-Ribose as a supplement for cardiac energy metabolism
  4. Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans
  5. D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study
  6. D-ribose aids advanced ischemic heart failure patients
  7. Effects of ribose on exercise-induced ischaemia in stable coronary artery disease
  8. Evaluation of the anti-ischemic effects of D-ribose during dobutamine stress echocardiography: a pilot study
  9. Formation of inosine monophosphate (IMP) in human skeletal muscle during incremental dynamic exercise
  10. The effect of high-intensity training on purine metabolism in man
  11. Urate uptake and lowered ATP levels in human muscle after high-intensity intermittent exercise
  12. AMP deamination and purine exchange in human skeletal muscle during and after intense exercise
  13. Decreased resting levels of adenine nucleotides in human skeletal muscle after high-intensity training
  14. Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women
  15. Reduced high-energy phosphate levels in the painful muscles of patients with primary fibromyalgia
  16. Benefit of ribose in a patient with fibromyalgia
  17. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study


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