Dang Shen - NutraPedia

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Dang Shen (Codonopsis pilosula) Health Overview

1) Conditions Studied

Dang Shen has been studied for a variety of conditions, including:

Anemia
Chronic fatigue syndrome
Weak immune system
Digestive disorders
Respiratory tract infections

2) Efficacy in Treating Conditions

While traditional use suggests efficacy, scientific evidence varies for these conditions. Some studies have shown potential benefits, but more research is needed to confirm the effectiveness of Dang Shen in treating these specific conditions.

3) Health Benefits

Dang Shen is believed to offer several health benefits, such as:

Boosting the immune system
Improving digestive health
Increasing energy levels
Enhancing respiratory function
Possessing anti-inflammatory properties

4) Potential Downsides

While Dang Shen is generally considered safe, it may have downsides, including:

Interactions with certain medications
Possible side effects, such as nausea or diarrhea
Not recommended for pregnant or breastfeeding women due to lack of safety data

5) Genetic Variations Impact

There is limited research on the interaction between Dang Shen and specific genetic variations. Individual responses to Dang Shen may vary, and certain genetic profiles may influence its effectiveness or risk of side effects. Consultation with a healthcare provider or a genetic counselor is advisable for personalized advice.

Dang Shen (Codonopsis pilosula) Research Summary

The historical identity of "Chinese ginseng" referenced in ancient texts is likely Codonopsis pilosula (Dang Shen), not Panax ginseng. This determination is based on descriptions from ancient texts that match Codonopsis pilosula's characteristics and cultivation areas.

Quality Assessment of Radix Codonopsis

Researchers have developed a new method for assessing the quality of Radix Codonopsis (Dangshen) using proton nuclear magnetic resonance ((1)H NMR), which provides precise measurement of certain chemical compounds within the herb.

Discovery of New Compounds

Three new triterpenyl esters, codonopilates A-C, and fourteen known substances were identified from Codonopsis pilosula, with some compounds being isolated from the plant for the first time.

Extraction Techniques

An optimized supercritical CO2 extraction method was developed for extracting lobetyolin from Codonopsis pilosula, showing more effectiveness than traditional techniques.

Polysaccharides Analysis

A polysaccharide (S-CPPA1) isolated from Codonopsis pilosula showed a protective effect against kidney damage in rats, while another study detailed the structure of a heteropolysaccharide using capillary electrophoresis.

Antioxidant Activities

Extracts from Codonopsis pilosula roots demonstrated significant antioxidant activities, with potential as affordable alternatives to other ginseng species.

Cognitive Function Enhancement

A combination of Dangshen and Ginkgo biloba was found to enhance cognitive function and health status in a study with 60 participants.

Immunomodulatory Effects

A water-soluble polysaccharide from Codonopsis pilosula, CPP, showed potential as a non-toxic vaccine adjuvant, enhancing the immune response in mice.

Antitumor and Immunomodulatory Properties

Research indicates that the sugar side chains of a polysaccharide derived from Codonopsis pilosula are crucial for its antitumor and immune-activating properties.

Immune System Support in Cancer Treatments

A medicinal herb complex containing Codonopsis pilosula was found to enhance immune function in cancer patients undergoing chemotherapy or radiotherapy.

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