Ecklonia Cava: An Overview

1) Conditions Studied

Ecklonia Cava has been studied for a variety of conditions, including but not limited to:

• Oxidative stress
• Inflammation
• Diabetes
• Obesity
• Cardiovascular diseases
• Neurodegenerative diseases
• Sexual dysfunction

2) Efficacy in Treating Conditions

The effectiveness of Ecklonia Cava in treating the aforementioned conditions has been evaluated in various studies. While some research indicates potential health benefits, the evidence is not conclusive, and more clinical trials are needed to establish its efficacy.

3) Health Benefits

Reported health benefits of Ecklonia Cava include:

• Antioxidant activity
• Anti-inflammatory effects
• Improvement in blood circulation
• Enhancement of cognitive function
• Potential weight loss aid
• Support in managing blood sugar levels
• Cholesterol-lowering effects

4) Downsides

While Ecklonia Cava is generally considered safe for consumption, some potential downsides include:

• Insufficient evidence for some claimed benefits
• Possible allergic reactions in sensitive individuals
• Interactions with certain medications
• Lack of regulation in the supplement industry, which may lead to inconsistent product quality

5) Impact on Genetic Variations

There is limited information regarding the interaction of Ecklonia Cava with specific genetic variations. Some compounds within Ecklonia Cava may have different effects depending on an individual's genetic makeup, but currently, there is no substantial evidence to make definitive claims about its benefits or harms for particular genetic variations.

Ecklonia Cava Research Summary

Ecklonia cava, a brown seaweed, has been extensively studied for its health benefits. Research shows its enzymatic extract can enhance immune response by promoting lymphocyte proliferation through the NF-κB activation pathway, influencing interleukin-2 production. Phlorotannins from E. cava exhibit multiple biological activities, including antioxidant, anticancer, antidiabetic, anti-HIV, antihypertensive, anti-allergy effects, and enzyme inhibition.

An antioxidant and anti-inflammatory agent derived from E. cava, Seapolynol™, significantly reduced cholesterol and inflammation in high cholesterol patients over 12 weeks without major side effects, with notable benefits for those with metabolic syndrome.

Studies highlight E. cava's potential in cosmetics, with compounds like 7-phloroeckol showing strong tyrosinase inhibition and melanin production reduction, outperforming standard inhibitors, suggesting application in skin-whitening products.

The antioxidant properties of E. cava's phlorotannins are confirmed by various assays, indicating their potential in functional foods, cosmetics, and pharmaceuticals. The compounds also exhibit neuroprotective, anti-diabetic, radioprotective, anti-inflammatory, and anti-tumor activities, highlighting E. cava's therapeutic potential across various health conditions.

In addition, E. cava extracts have been shown to protect against UV-B radiation damage in zebrafish embryos and reduce oxidative stress in human skin cells. E. cava's efficacy in hair growth stimulation and its potential as a dietary approach for managing blood glucose levels in diabetes have also been explored.

Overall, Ecklonia cava holds promise for its immunomodulatory, antioxidant, anti-inflammatory, and disease-preventive properties, with a need for further studies to confirm these findings and extend its applications.

References:

1. Enzymatic extract from Ecklonia cava induces the activation of lymphocytes by IL-2 production through the classical NF-κB pathway
2. Phlorotannins from Ecklonia cava (Phaeophyceae): biological activities and potential health benefits
3. Effects of Ecklonia cava polyphenol in individuals with hypercholesterolemia: a pilot study
4. Inhibitory effect of phlorotannins isolated from Ecklonia cava on mushroom tyrosinase activity and melanin formation in mouse B16F10 melanoma cells
5. Chemical components and its antioxidant properties in vitro: an edible marine brown alga, Ecklonia cava
6. Evaluation of antioxidant properties of a new compound, pyrogallol-phloroglucinol-6,6'-bieckol isolated from brown algae, Ecklonia cava
7. Photo-oxidative stress by ultraviolet-B radiation and antioxidative defense of eckstolonol in human keratinocytes
8. 1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin inhibits adipocyte differentiation of 3T3-L1 fibroblasts
9. Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes
10. Anti-inflammatory effect of fucoidan extracted from Ecklonia cava in zebrafish model
11. Immunomodulatory effects of an enzymatic extract from Ecklonia cava on murine splenocytes
12. Antioxidant and antiinflammatory activities of ventol, a phlorotannin-rich natural agent derived from Ecklonia cava, and its effect on proteoglycan degradation in cartilage explant culture
13. A polysaccharide isolated from Ecklonia cava fermented by Lactobacillus brevis inhibits the inflammatory response by suppressing the activation of nuclear factor-κB in lipopolysaccharide-induced RAW 264.7 macrophages
14. Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death
15. Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity
16. Improvement of memory by dieckol and phlorofucofuroeckol in ethanol-treated mice: possible involvement of the inhibition of acetylcholinesterase
17. Protective efficacy of an Ecklonia cava extract used to treat transient focal ischemia of the rat brain
18. Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H2O2-induced oxidative stress in murine hippocampal HT22 cells
19. Inhibitory effects and molecular mechanism of dieckol isolated from marine brown alga on COX-2 and iNOS in microglial cells
20. Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-kappaB pathways
21. Depressive effects on the central nervous system and underlying mechanism of the enzymatic extract and its phlorotannin-rich fraction from Ecklonia cava edible brown seaweed
22. Effect of phlorotannins isolated from Ecklonia cava on angiotensin I-converting enzyme (ACE) inhibitory activity
23. Effects of 12-week oral supplementation of Ecklonia cava polyphenols on anthropometric and blood lipid parameters in overweight Korean individuals: a double-blind randomized clinical trial
24. Ecklonia cava extracts inhibit lipopolysaccharide induced inflammatory responses in human endothelial cells
25. Protective effects of enzymatic digest from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells
26. Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells
27. Ecklonia cava Inhibits Glucose Absorption and Stimulates Insulin Secretion in Streptozotocin-Induced Diabetic Mice
28. Dieckol isolated from Ecklonia cava inhibits alpha-glucosidase and alpha-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice
29. Insulinotrophic and hypolipidemic effects of Ecklonia cava in streptozotocin-induced diabetic mice
30. Bioactive compounds extracted from Ecklonia cava by using enzymatic hydrolysis protects high glucose-induced damage in INS-1 pancreatic β-cells
31. Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus
32. Polyphenol-Rich Fraction of Brown Alga Ecklonia cava Collected from Gijang, Korea, Reduces Obesity and Glucose Levels in High-Fat Diet-Induced Obese Mice
33. 6,6'-Bieckol, isolated from marine alga Ecklonia cava, suppressed LPS-induced nitric oxide and PGE₂ production and inflammatory cytokine expression in macrophages: the inhibition of NFκB
34. Phloroglucinol (PG) purified from Ecklonia cava attenuates radiation-induced apoptosis in blood lymphocytes and splenocytes
35. Dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression
36. Phloroglucinol (1,3,5-trihydroxybenzene) protects against ionizing radiation-induced cell damage through inhibition of oxidative stress in vitro and in vivo
37. Ecklonia cava extract suppresses the high-affinity IgE receptor, FcepsilonRI expression
38. Effects of Ecklonia cava ethanolic extracts on airway hyperresponsiveness and inflammation in a murine asthma model: role of suppressor of cytokine signaling
39. Ecklonia cava polyphenol protects the liver against ethanol-induced injury in rats
40. Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt
41. Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor
42. Antioxidant dieckol downregulates the Rac1/ROS signaling pathway and inhibits Wiskott-Aldrich syndrome protein (WASP)-family verprolin-homologous protein 2 (WAVE2)-mediated invasive migration of B16 mouse melanoma cells
43. Cytoprotective effects of triphlorethol-A against formaldehyde-induced oxidative damage and apoptosis: role of mitochondria-mediated caspase-dependent pathway
44. An antioxidative and antiinflammatory agent for potential treatment of osteoarthritis from Ecklonia cava
45. Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: implication for chronic articular disease
46. Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways
47. Effect of supplementation with Ecklonia cava polyphenol on endurance performance of college students
48. Hepatoprotective effects of dieckol-rich phlorotannins from Ecklonia cava, a brown seaweed, against ethanol induced liver damage in BALB/c mice
49. Inhibitory effects of Ecklonia cava extract on high glucose-induced hepatic stellate cell activation
50. Phloroglucinol inhibits the bioactivities of endothelial progenitor cells and suppresses tumor angiogenesis in LLC-tumor-bearing mice
51. Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity
52. Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway
53. Inhibition of the expression on MMP-2, 9 and morphological changes via human fibrosarcoma cell line by 6,6'-bieckol from marine alga Ecklonia cava
54. Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation
55. Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxidase
56. Redox changes of cultured endothelial cells and actin dynamics
57. Dieckol from Ecklonia cava suppresses the migration and invasion of HT1080 cells by inhibiting the focal adhesion kinase pathway downstream of Rac1-ROS signaling
58. Induction of apoptosis by phloroglucinol derivative from Ecklonia Cava in MCF-7 human breast cancer cells
59. Effect of Dieckol, a component of Ecklonia cava, on the promotion of hair growth
60. Protective effects of phlorotannins against ultraviolet B radiation in zebrafish (Danio rerio)
61. Inhibitory phlorotannins from the edible brown alga Ecklonia stolonifera on total reactive oxygen species (ROS) generation
62. Eckol inhibits ultraviolet B-induced cell damage in human keratinocytes via a decrease in oxidative stress
63. Screening of marine algae for potential tyrosinase inhibitor: those inhibitors reduced tyrosinase activity and melanin synthesis in zebrafish
64. Molecular docking studies of a phlorotannin, dieckol isolated from Ecklonia cava with tyrosinase inhibitory activity

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