Fadogia Agrestis - NutraPedia

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Fadogia Agrestis Overview

1) Studied Conditions

Fadogia Agrestis has been studied for a variety of conditions, notably for its potential to enhance sexual performance and to boost testosterone levels in men. It has also been researched for its anti-inflammatory and analgesic properties, and its potential effects on endurance and athletic performance.

2) Efficacy in Treating Conditions

Research is limited and primarily consists of animal studies. Some studies suggest that Fadogia Agrestis may increase sexual behavior and testosterone levels in rats, but there is a lack of robust clinical trials to confirm these effects in humans. Therefore, its efficacy in treating these conditions is still uncertain and should be approached with caution.

3) Health Benefits

Fadogia Agrestis is purported to have several health benefits, including increased libido, enhanced sexual performance, and elevated testosterone levels. Additionally, it has been associated with anti-inflammatory and analgesic effects, which could be beneficial for managing pain and inflammation. However, more research is needed to substantiate these claims.

4) Potential Downsides

As with many supplements, Fadogia Agrestis may have downsides. Potential risks include toxicity and damage to organs such as the liver and kidneys when consumed in high doses or for prolonged periods. There is also a lack of information on its long-term safety and side effects profile, which warrants caution and further investigation.

5) Impact on Genetic Variations

Currently, there is no substantial evidence to suggest that Fadogia Agrestis is either particularly beneficial or harmful for specific genetic variations. Genetic factors can influence an individual's response to supplements, but without targeted research into the genetics of Fadogia Agrestis response, it is difficult to make any definitive conclusions in this area.

Research Summary on Fadogia Agrestis

Isolation of Monoterpene Glycosides

Researchers isolated six monoterpene glycosides from Fadogia agrestis, identified as 2,6-dimethyl-2(E),6(Z)-octadiene-1,8-diol derivatives with rhamnopyranose and glucopyranose units. These structures were determined using mass spectrometry, NMR spectroscopy, and chemical analysis.

Aphrodisiac Effects and Testosterone Levels

The aqueous extract of Fadogia agrestis stem was studied for its aphrodisiac effects and impact on testosterone levels in male albino rats. The extract contains alkaloids and saponins, and at various doses, it significantly increased sexual activity and serum testosterone levels in a dose-dependent manner.

Impact on Testicular Functions

An aqueous extract from Fadogia agrestis stem was investigated for its effects on testicular functions in male rats. It was found to affect various testicular functions, but after a recovery period, some functions improved, particularly at the lowest dose, suggesting potential safety in traditional medicine use.

Structural Characterization of Compounds

From the dried roots of Vangueria agrestis (also known as Fadogia agrestis), researchers isolated and characterized triterpenoid, benzophenone, and iridoid glycosides. Two new metabolites were identified, some exhibiting anti-infective properties against Trypanosoma brucei.

Antimalarial Activity

An ethnobotanical survey in Burkina Faso identified plants used in traditional medicine, including Fadogia agrestis, for antimalarial properties. The plant extracts showed notable antiplasmodial activity against a chloroquine-resistant strain of Plasmodium falciparum.

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