Gamma Oryzanol Research Summary

Gamma Oryzanol (γ-oryzanol), a compound found in rice bran oil, has been the focus of various studies due to its potential health benefits. This summary synthesizes research findings on γ-oryzanol, highlighting its extraction, bioactivity, and health implications.

Extraction and Analysis

• A non-aqueous hydrostatic countercurrent chromatography technique was developed to extract γ-oryzanol from crude rice bran oil with high purity.
• An improved HPLC method was created to measure γ-oryzanol and vitamin E isomers in rice, offering rapid and reliable quantification.
• LC-MS/MS analysis was used to identify ferulic acid esters and other components in γ-oryzanol, providing new insights into rice bran oil's composition.

Health Benefits and Effects

• Studies suggest γ-oryzanol may have antidiabetic properties, potentially reducing the prevalence of diabetes or improving prediabetes conditions.
• Rice bran oil containing γ-oryzanol shows promising results in managing hyperlipoproteinemias by reducing cholesterol and triglyceride levels while increasing HDL cholesterol.
• Research indicates that γ-oryzanol may not cause significant drug interactions with medications metabolized by cytochrome P450 enzymes.
• γ-Oryzanol has been found to positively affect glucose metabolism and reduce preferences for high-fat foods in mice.

Other Research Findings

• γ-Oryzanol encapsulation in niosomes increased skin absorption, leading to potential applications in transdermal delivery systems.
• Gel and cream formulations containing niosomes with rice bran bioactive compounds have exhibited anti-aging benefits in clinical studies.
• γ-Oryzanol supplementation did not enhance performance or physiological parameters in weight-trained males over a 9-week resistance exercise training period.
• Phytosteryl ferulates, including γ-oryzanol, demonstrated antioxidative and anti-inflammatory properties in various assays.
• γ-Oryzanol reduced tumor mass in mice by activating immune responses and inhibiting angiogenesis within tumors.
• Oral administration of γ-oryzanol improved adiponectin levels in mice, suggesting potential benefits for metabolic and insulin resistance syndromes.

Conclusions

Overall, research on γ-oryzanol has shed light on its potential health benefits, particularly for metabolic and cardiovascular health. While further studies are necessary to fully understand its mechanisms and applications, γ-oryzanol remains a promising natural compound for nutritional and therapeutic uses.

References:

1. One-step isolation of γ-oryzanol from rice bran oil by non-aqueous hydrostatic countercurrent chromatography
2. Characterization of high-value bioactives in some selected varieties of Pakistani Rice (Oryza sativa L.)
3. An improved high-performance liquid chromatographic method for simultaneous determination of tocopherols, tocotrienols and γ-oryzanol in rice
4. Quantification of tocopherols, tocotrienols, and γ-oryzanol contents and their distribution in some commercial rice varieties in Taiwan
5. Effect of saponification on composition of unsaponifiable matter in rice bran oil
6. Antidiabetic effects of a standardized Egyptian rice bran extract
7. Rice bran oil and gamma-oryzanol in the treatment of hyperlipoproteinaemias and other conditions
8. Characterization of triterpene alcohol and sterol ferulates in rice bran using LC-MS/MS
9. Transdermal absorption enhancement of rice bran bioactive compounds entrapped in niosomes
10. Anti-aging efficacy of topical formulations containing niosomes entrapped with rice bran bioactive compounds
11. Effect of gamma-oryzanol on cytochrome P450 activities in human liver microsomes
12. Brown rice and its component, γ-oryzanol, attenuate the preference for high-fat diet by decreasing hypothalamic endoplasmic reticulum stress in mice
13. Effect of oryzanol and ferulic acid on the glucose metabolism of mice fed with a high-fat diet
14. Gamma-oryzanol ameliorates insulin resistance and hyperlipidemia in rats with streptozotocin/nicotinamide-induced type 2 diabetes
15. [Clinical effect of gamma-oryzanol on climacteric disturbance -on serum lipid peroxides (author's transl)]
16. Hot flashes--a review of the literature on alternative and complementary treatment approaches
17. Menopausal problems and acupuncture
18. Acupuncture for vasomotor menopausal symptoms: a systematic review
19. Effect of gamma-oryzanol on the bioaccessibility and synthesis of cholesterol
20. γ-Oryzanol reduces adhesion molecule expression in vascular endothelial cells via suppression of nuclear factor-κB activation
21. Similar cholesterol-lowering properties of rice bran oil, with varied gamma-oryzanol, in mildly hypercholesterolemic men
22. The effects of gamma-oryzanol supplementation during resistance exercise training
23. Antioxidant, free radical-scavenging, and NF-kappaB-inhibitory activities of phytosteryl ferulates: structure-activity studies
24. Dietary rice bran component γ-oryzanol inhibits tumor growth in tumor-bearing mice
25. Dual inhibition of γ-oryzanol on cellular melanogenesis: inhibition of tyrosinase activity and reduction of melanogenic gene expression by a protein kinase A-dependent mechanism
26. The insulin-sensitizing role of the fat derived hormone adiponectin
27. Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes
28. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
29. The effects of hydroxycinnamic acid derivatives on adiponectin secretion
30. γ-Oryzanol recovers mouse hypoadiponectinemia induced by animal fat ingestion
31. Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide
32. Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade
33. Oral administration of γ-aminobutyric acid and γ-oryzanol prevents stress-induced hypoadiponectinemia