Gotu Kola

1) Conditions Studied for Gotu Kola Use

Gotu Kola, a traditional herb used in Ayurvedic and Chinese medicine, has been studied for various health conditions. Some of these include:

• Chronic venous insufficiency
• Wound healing
• Anxiety and stress
• Improving cognitive function
• Skin conditions like psoriasis and leprosy
• Preventing stretch marks
• Improving circulation and reducing swelling

2) Efficacy in Treating Conditions

The effectiveness of Gotu Kola in treating these conditions varies:

• Some studies have shown improvements in symptoms of chronic venous insufficiency such as reducing swelling and improving blood flow.
• There is evidence suggesting Gotu Kola may aid in wound healing and skin conditions due to its triterpenoids content, which can increase antioxidants and strengthen the skin.
• Research on its effects on cognitive function and anxiety is promising, but more rigorous studies are needed to confirm these benefits.
• There is limited and inconclusive evidence for its use in preventing stretch marks.

3) Health Benefits of Gotu Kola

Gotu Kola is attributed with several health benefits:

• May enhance cognitive function and memory
• Potential to reduce anxiety and stress
• Can improve circulation and reduce swelling in the extremities
• Possibly promotes skin health and wound healing
• Might reduce symptoms of chronic venous insufficiency

4) Potential Downsides of Gotu Kola

While Gotu Kola is generally considered safe, it does have potential downsides:

• May cause side effects such as headache, dizziness, and nausea in some individuals.
• Prolonged use can lead to skin sensitivity to sunlight and dermatitis in rare cases.
• Gotu Kola might interact with medications, particularly sedatives and drugs metabolized by the liver.
• Pregnant and breastfeeding women are typically advised to avoid it due to insufficient safety data.

5) Genetics and Gotu Kola

There is limited research on Gotu Kola's benefits or harm in relation to specific genetic variations. Certain genetic profiles may influence an individual's metabolism and response to herbal supplements, but concrete evidence linking Gotu Kola to particular genetic variations is sparse. Personal genetic factors might impact efficacy and safety, so it is advisable to consult with a healthcare provider before using Gotu Kola, especially for those with known genetic conditions or predispositions.

Gotu Kola (Centella asiatica) and Its Effects on Health

Gotu Kola, known scientifically as Centella asiatica, is a medicinal herb that has been utilized for a wide range of therapeutic purposes. Its primary active components, triterpenoid saponins, are believed to be responsible for its effectiveness in treating various ailments. Conditions such as skin diseases, gastrointestinal disorders, female genitourinary issues, anxiety, and cognitive impairment have been addressed using Gotu Kola.

Pharmacology and Clinical Evidence

Comprehensive reviews have covered the pharmacology, mechanisms of action, and evidence from clinical studies that support the medicinal use of Gotu Kola. Preclinical and clinical studies have shown significant reductions in symptoms of anxiety, stress, and related depression when Gotu Kola was administered. It has also demonstrated cognitive function improvement and potential as an anxiolytic agent for generalized anxiety disorder (GAD).

Safety and Interactions

Understanding the safety concerns and potential for drug-herb interactions is crucial for the safe and effective use of Gotu Kola. Further research is encouraged to fully establish its therapeutic potential and safety profile.

Nutrition and Wound Healing

Nutrition plays a critical role in the process of wound healing. Gotu Kola, along with other botanical medicines, has been recognized for promoting wound healing due to its positive effects on cellular activities and the production of essential nutrients.

Neurological Disorders and Cognitive Enhancement

Gotu Kola is traditionally associated with neuroprotective and cognitive-enhancing properties, particularly in the treatment of memory loss and cognitive deficits. Innovations in herbal extraction methodologies and formulations are focused on improving the therapeutic properties of Gotu Kola for various human ailments.

Research and Analysis Methods

Various studies have presented improved methods for analyzing the compounds in Gotu Kola, such as high-performance liquid chromatography (HPLC-UV) and high-performance thin-layer chromatography (HPTLC). These methods have been validated for routine analysis of Gotu Kola samples.

Antiproliferative and Saponin Compounds

Research has isolated several compounds from Gotu Kola with antiproliferative activity against different cancer cell lines. Additionally, new saponin compounds have been identified, contributing to the understanding of the chemical components responsible for Gotu Kola's medicinal properties.

Conclusion

Gotu Kola has been traditionally used for its various health benefits, especially in promoting wound healing and enhancing cognitive function. While there is scientific support for some of its therapeutic properties, further research is necessary to validate its safety and efficacy for medical use.

References:

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29. In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19)
30. Madecassoside suppresses LPS-induced TNF-alpha production in cardiomyocytes through inhibition of ERK, p38, and NF-kappaB activity
31. Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress
32. Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-kappa B inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways
33. Asiaticoside induction for cell-cycle progression, proliferation and collagen synthesis in human dermal fibroblasts
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37. Rictor regulates MMP-9 activity and invasion through Raf-1-MEK-ERK signaling pathway in glioma cells
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39. Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro
40. Exogenous BDNF, NT-3 and NT-4 differentially regulate neurite outgrowth in cultured hippocampal neurons
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45. Centella asiatica water extract inhibits iPLA2 and cPLA2 activities in rat cerebellum
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48. Mitoprotective effect of Centella asiatica against aluminum-induced neurotoxicity in rats: possible relevance to its anti-oxidant and anti-apoptosis mechanism
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51. Promotion of cell death or neurite outgrowth in PC-12 and N2a cells by the fungal alkaloid militarinone A depends on basal expression of p53
52. Essential role of ERK activation in neurite outgrowth induced by α-lipoic acid
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54. Centella asiatica (L.) leaf extract treatment during the growth spurt period enhances hippocampal CA3 neuronal dendritic arborization in rats
55. Enhancement of hippocampal CA3 neuronal dendritic arborization by Centella asiatica (Linn) fresh leaf extract treatment in adult rats
56. Evaluation of amygdaloid neuronal dendritic arborization enhancing effect of Centella asiatica (Linn) fresh leaf extract in adult rats
57. Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats
58. Neuroprotective evaluation of standardized extract of Centella asciatica in monosodium glutamate treated rats
59. Prophylactic neuroprotective property of Centella asiatica against 3-nitropropionic acid induced oxidative stress and mitochondrial dysfunctions in brain regions of prepubertal mice
60. Effect of Centella asiatica leaf powder on oxidative markers in brain regions of prepubertal mice in vivo and its in vitro efficacy to ameliorate 3-NPA-induced oxidative stress in mitochondria
61. Comparison of bilaterally 6-OHDA- and MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory alterations
62. Running wheel activity restores MPTP-induced functional deficits
63. Neuroprotective signaling mechanisms of telomerase are regulated by brain-derived neurotrophic factor in rat spinal cord motor neurons
64. Glutamate and neurotrophic factors in neuronal plasticity and disease
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66. Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice
67. Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica
68. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial
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71. Centella asiatica Attenuates D-Galactose-Induced Cognitive Impairment, Oxidative and Mitochondrial Dysfunction in Mice
72. Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats
73. Treatment with Centalla asiatica (Linn) fresh leaf extract enhances learning ability and memory retention power in rats
74. Effects of asiatic acid on passive and active avoidance task in male Spraque-Dawley rats
75. Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells
76. Madecassoside reduces ischemia-reperfusion injury on regional ischemia induced heart infarction in rat
77. Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells
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80. Treatment of diabetic microangiopathy and edema with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled randomized study
81. Flight microangiopathy in medium- to long-distance flights: prevention of edema and microcirculation alterations with total triterpenic fraction of Centella asiatica
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98. The efficacy and side effects of oral Centella asiatica extract for wound healing promotion in diabetic wound patients
99. Anti-rheumatoid arthritic effect of madecassoside on type II collagen-induced arthritis in mice
100. Brain-specific endothelial induction of prostaglandin E(2) synthesis enzymes and its temporal relation to fever
101. Prostaglandin E(2)-synthesizing enzymes in fever: differential transcriptional regulation
102. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
103. An antipyretic role for interleukin-10 in LPS fever in mice
104. Antipyretic and anti-inflammatory effects of asiaticoside in lipopolysaccharide-treated rat through up-regulation of heme oxygenase-1
105. Anti-herpes simplex virus activities of crude water extracts of Thai medicinal plants
106. An experimental study of the anti-HSV-II action of 500 herbal drugs
107. Madecassoside attenuates inflammatory response on collagen-induced arthritis in DBA/1 mice
108. The inductive effects of Centella asiatica on rat spermatogenic cell apoptosis in vivo
109. Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats
110. Effect of Centella asiatica Linn on physical and chemical factors induced gastric ulceration and secretion in rats
111. Effects of asiaticoside on levels of podocyte cytoskeletal proteins and renal slit diaphragm proteins in adriamycin-induced rat nephropathy
112. Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis
113. Protective role of Centella asiatica on lead-induced oxidative stress and suppressed reproductive health in male rats
114. Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model
115. Identification of Major Active Ingredients Responsible for Burn Wound Healing of Centella asiatica Herbs
116. TGF-beta signaling and the fibrotic response
117. Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts
118. Standardized Clitoria ternatea leaf extract as hyaluronidase, elastase and matrix-metalloproteinase-1 inhibitor
119. Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers
120. Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling
121. An animal model of solar-aged skin: histological, physical, and visible changes in UV-irradiated hairless mouse skin
122. Long-term topical oestrogen treatment of sun-exposed facial skin in post-menopausal women does not improve facial wrinkles or skin elasticity, but induces matrix metalloproteinase-1 expression
123. Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts
124. Centella asiatica protects against UVB-induced HaCaT keratinocyte damage through microRNA expression changes
125. Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice
126. Diabetes and wound healing
127. In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica
128. Prophylaxis of Striae gravidarum with a topical formulation. A double blind trial
129. Use of a specific anti-stretch mark cream for preventing or reducing the severity of striae gravidarum. Randomized, double-blind, controlled trial
130. Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells
131. Apoptosis induction of Centella asiatica on human breast cancer cells
132. Antiproliferative, cell-cycle dysregulation effects of novel asiatic acid derivatives on human non-small cell lung cancer cells
133. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells
134. Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells
135. The role of calcium in the regulation of apoptosis
136. Calcium and apoptosis: facts and hypotheses
137. Disruption of the endoplasmic reticulum and increases in cytoplasmic calcium are early events in cell death induced by the natural triterpenoid Asiatic acid
138. Antioxidant synergism between ethanolic Centella asiatica extracts and α-tocopherol in model systems
139. Gotu Kola induced hepatotoxicity in a child - need for caution with alternative remedies
140. Hepatotoxicity associated with the ingestion of Centella asiatica

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