Guduchi Overview

1) Conditions Studied

Guduchi, also known as Tinospora cordifolia, has been studied for a variety of conditions including:

• Immune system enhancement
• Arthritis and inflammation
• Diabetes
• Hepatic disorders
• Respiratory infections
• Stress and anxiety
• Skin disorders
• Gastrointestinal issues

2) Effectiveness in Treating Conditions

While traditional Ayurvedic medicine endorses the use of Guduchi for various conditions, scientific evidence varies. Some studies suggest benefits for immune system support and reduction of diabetic symptoms, but more rigorous, large-scale clinical trials are needed to establish its efficacy conclusively.

3) Health Benefits

Guduchi is believed to offer several health benefits:

• Boosting immune system function
• Antioxidant properties that combat free radicals
• Anti-inflammatory effects that may alleviate pain and swelling
• Potential blood sugar level regulation for diabetics
• May aid in liver detoxification and protection
• Could help reduce symptoms of stress and anxiety

4) Downsides

Guduchi is generally considered safe when used in moderation. However, there can be downsides such as:

• Allergic reactions in sensitive individuals
• Potential for lowered blood sugar levels, which can be an issue for diabetics on medication
• Insufficient evidence on its safety for pregnant or breastfeeding women
• Interactions with other medications, particularly those that are processed by the liver

5) Genetic Variations and Guduchi

Research on the effects of Guduchi in relation to specific genetic variations is limited. However, individual responses to herbal supplements can vary, and genetic makeup might influence efficacy and safety. It is always recommended to consult with a healthcare provider before starting any new supplement regimen, especially if there is a known genetic predisposition to certain conditions or medication sensitivities.

Summary on Guduchi (Tinospora cordifolia) Research

Guduchi's Genetic Diversity and Medicinal Properties: Research using Random Amplified Polymorphic DNA markers has shown that Guduchi (Tinospora cordifolia) clones exhibit a very close genetic distance, demonstrating its usefulness for species identification and characterization of genetic variation. This information is crucial for the conservation of this medically important plant.

Guduchi's Efficacy in Treating Various Conditions: Studies reveal that Guduchi lotion is an effective alternative to permethrin in treating scabies in children. Additionally, Guduchi stem extract inhibits alpha-glucosidase, offering therapeutic potential for diabetes mellitus treatment. In cases of allergic rhinitis, Guduchi extract significantly decreases symptoms, with high efficacy and patient tolerance reported.

Guduchi Formulations and Effects: Research comparing Ayurvedic formulations of Guduchi oil and ghee finds that the medium used influences therapeutic outcomes, with oil showing immunostimulating properties, while ghee exhibits anti-stress and immunosuppressive activities.

Guduchi's Role in Immune System Enhancement: Guduchi is notable for its immune-enhancing effects. Studies have identified specific immunomodulatory compounds in Guduchi, with seven compounds isolated that notably enhance phagocytic activity and reactive oxygen species generation.

Guduchi's Safety Profile: Guduchi has been evaluated for its genotoxic potential, with studies indicating it is not genotoxic at tested doses, confirming its safety.

Guduchi's Therapeutic Compounds: Research has identified and characterized various compounds in Guduchi through techniques like high-performance liquid chromatography and gas chromatography-mass spectrometry. These include alkaloids like berberine, jatrorrhizine, and magnoflorine, which have potential therapeutic or quality-marker significance.

Guduchi's Antioxidant and Anti-Diabetic Potential: Guduchi exhibits antioxidant effects and has been shown to protect against aflatoxin-induced kidney toxicity. Additionally, components like saponarin from Guduchi leaves demonstrate hypoglycemic effects by inhibiting alpha-glucosidase and sucrase enzymes.

Conclusion: Guduchi (Tinospora cordifolia) has been extensively studied for its vast range of therapeutic properties, including genetic variation studies for conservation, treatment efficacy for scabies, allergic rhinitis, and diabetes, its role in enhancing the immune system, and its safety and genotoxic profile. Various compounds within Guduchi have been identified, offering a deeper understanding of its pharmacological effects and potential benefits in treating a wide array of conditions.

References:

1. Genetic diversity analysis of Tinospora cordifolia germplasm collected from northwestern Himalayan region of India
2. Identification of Tinospora cordifolia (Willd.) Miers ex Hook F & Thomas using RAPD markers
3. Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial
4. Alpha glucosidase inhibition by stem extract of Tinospora cordifolia
5. Efficacy of Tinospora cordifolia in allergic rhinitis
6. A comparative pharmacological evaluation of Taila (oil) and Ghrita (ghee) prepared with Guduchi (Tinospora cordifolia)
7. Tinospora cordifolia: One plant, many roles
8. Immunomodulatory active compounds from Tinospora cordifolia
9. Tinospora cordifolia, a safety evaluation
10. HPLC Estimation of berberine in Tinospora cordifolia and Tinospora sinensis
11. Polysaccharide enriched immunomodulatory fractions from Tinospora cordifolia (Willd) miers ax hook. f. & Thoms
12. Isolation of jatrorrhizine from Tinospora cordifolia roots
13. Ameliorative effects of tinospora cordifolia root extract on histopathological and biochemical changes induced by aflatoxin-b(1) in mice kidney
14. A new antifeedant clerodane diterpenoid from Tinospora cordifolia
15. Immunopotentiating compounds from Tinospora cordifolia
16. Cordifolide A, a sulfur-containing clerodane diterpene glycoside from Tinospora cordifolia
17. Structure of tinosporide, a diterpenoid furanolactone from Tinospora cordifolia Miers
18. A validated HPLC method for estimation of cordifolioside A in Tinospora cordifolia, Miers and marketed formulations
19. Cordifolisides A, B, C: norditerpene furan glycosides from Tinospora cordifolia
20. New phytoconstituents from the stem bark of Tinospora cordifolia Miers
21. Hypoglycemic activity of the antioxidant saponarin, characterized as alpha-glucosidase inhibitor present in Tinospora cordifolia
22. Phenolic constituents in dried flowers of aloe vera (Aloe barbadensis) and their in vitro antioxidative capacity
23. Octacosanol isolated from Tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF-B and its DNA binding activity
24. Physiological effects of a novel immune stimulator drug, (1,4)-α-D-glucan, in rats
25. Glycosyl composition of polysaccharide from Tinospora cordifolia
26. Glycosyl composition of polysaccharide from Tinospora cordifolia. II. Glycosyl linkages
27. G1-4 A, an arabinogalactan polysaccharide from Tinospora cordifolia increases dendritic cell immunogenicity in a murine lymphoma model
28. Immunostimulatory properties of the major protein from the stem of the Ayurvedic medicinal herb, guduchi (Tinospora cordifolia)
29. Anti-ulcer and anti-oxidant activity of pepticare, a herbomineral formulation
30. Antihyperglycaemic and antioxidant effect of hyponidd, an ayurvedic herbomineral formulation in streptozotocin-induced diabetic rats
31. Antihyperglycemic, antihyperlipidemic and antioxidant effects of Dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats
32. Efficacy and safety of livwin (polyherbal formulation) in patients with acute viral hepatitis: A randomized double-blind placebo-controlled clinical trial
33. Evaluation of anti-depressant and anxiolytic activity of Rasayana Ghana Tablet (A compound Ayurvedic formulation) in albino mice
34. Antipsychotic activity of aqueous ethanolic extract of tinospora cordifolia in amphetamine challenged mice model
35. Evidences for the Involvement of Monoaminergic and GABAergic Systems in Antidepressant-like Activity of Tinospora cordifolia in Mice
36. A comparative pharmacological investigation of three samples of 'Guduchi ghrita' for adaptogenic activity against forced swimming induced gastric ulceration and hematological changes in albino rats
37. Comparative evaluation of ethanolic extracts of Bacopa monnieri, Evolvulus alsinoides, Tinospora cordifolia and their combinations on cognitive functions in rats
38. Anti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L6 myotubes
39. Insulin sensitizing effect of 3 Indian medicinal plants: an in vitro study
40. Profile of aldose reductase inhibition, anti-cataract and free radical scavenging activity of selected medicinal plants: an attempt to standardize the botanicals for amelioration of diabetes complications
41. Effect of Tinospora cordifolia on experimental diabetic neuropathy
42. Isoquinoline alkaloids from Tinospora cordifolia inhibit rat lens aldose reductase
43. Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia
44. Amelioration of experimental diabetic neuropathy and gastropathy in rats following oral administration of plant (Eugenia jambolana, Mucuna pruriens and Tinospora cordifolia) extracts
45. Prevention and management of diabetic retinopathy in STZ diabetic rats by Tinospora cordifolia and its molecular mechanisms
46. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism
47. Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats
48. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes
49. Restoration of antioxidants by ethanolic Tinospora cordifolia in alloxan-induced diabetic Wistar rats
50. Prevention of experimental diabetic cataract by Indian Ayurvedic plant extracts
51. TNF-alpha is an independent serum marker for proliferative retinopathy in type 1 diabetic patients
52. Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy
53. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
54. Immunomodulatory role of Tinospora cordifolia as an adjuvant in surgical treatment of diabetic foot ulcers: a prospective randomized controlled study
55. Molecular events in the activation of B cells and macrophages by a non-microbial TLR4 agonist, G1-4A from Tinospora cordifolia
56. G1-4A, an immunomodulatory polysaccharide from Tinospora cordifolia, modulates macrophage responses and protects mice against lipopolysaccharide induced endotoxic shock
57. Mechanism of macrophage activation by (1,4)-alpha-D-glucan isolated from Tinospora cordifolia
58. In vitro NADH-oxidase, NADPH-oxidase and myeloperoxidase activity of macrophages after Tinospora cordifolia (guduchi) treatment
59. Src kinase participates in LPS-induced activation of NADPH oxidase
60. Effect of aqueous extract of Tinospora cordifolia on functions of peritoneal macrophages isolated from CCl4 intoxicated male albino mice
61. Can we do away with PTBD?
62. Immunomodulatory and antitumor actions of medicinal plant Tinospora cordifolia are mediated through activation of tumor-associated macrophages
63. Tumoricidal activity of monocyte-derived dendritic cells: evidence for a caspase-8-dependent, Fas-associated death domain-independent mechanism
64. Effect of Tinospora cordifolia on the antitumor activity of tumor-associated macrophages-derived dendritic cells
65. Carbon tetrachloride hepatotoxicity: an example of lethal cleavage
66. Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats
67. Effect of Tinospora cordifolia on gamma ray-induced perturbations in macrophages and splenocytes
68. Tinospora cordifolia induces colony stimulating activity in serum
69. Immunomodulatory effect of Tinospora cordifolia extract in human immuno-deficiency virus positive patients
70. The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis
71. Glucocorticoids affect human dendritic cell differentiation and maturation
72. The roles of interleukin-1 and interleukin-1 receptor antagonist in antigen-specific immune responses
73. An immunologically active arabinogalactan from Tinospora cordifolia
74. Comparable efficacy of standardized Ayurveda formulation and hydroxychloroquine sulfate (HCQS) in the treatment of rheumatoid arthritis (RA): a randomized investigator-blind controlled study
75. Management of Amavata with 'Amrita Ghrita': A clinical study
76. How does HIV cause depletion of CD4 lymphocytes? A mechanism involving virus signaling through its cellular receptors
77. Use of Tinospora cordifolia in HIV infection
78. Effects of Tinospora cordifolia supplementation on semen quality and hormonal profile in rams
79. Androgenic action of Tinospora cordifolia ethanolic extract in prostate cancer cell line LNCaP
80. Tinospora cordifolia induces enzymes of carcinogen/drug metabolism and antioxidant system, and inhibits lipid peroxidation in mice
81. Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage
82. Antifertility effect of Tinospora cordifolia (Willd.) stem extract in male rats
83. Itch and scratch: scabies and pediculosis
84. Nosocomial scabies

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