Xyzin Overview

1) Conditions Studied for Xyzin

Xyzin has been studied for use in treating conditions such as condition A, condition B, and condition C.

2) Efficacy of Xyzin in Treating Conditions

Research has shown mixed results for the efficacy of Xyzin. It appears to be effective for condition A, but there is less evidence supporting its use for conditions B and C.

3) Health Benefits of Xyzin

• Benefit 1
• Benefit 2
• Benefit 3

4) Downsides of Xyzin

While Xyzin has several benefits, it also has downsides such as side effect 1, side effect 2, and side effect 3.

5) Xyzin and Genetic Variations

Studies suggest that individuals with genetic variation 1 may see more benefits from Xyzin, while those with genetic variation 2 might be at a higher risk for certain side effects.

Artemisia iwayomogi (Haninjin) Research Summary

Development of Multiplex PCR Method: A multiplex PCR method was developed to differentiate Artemisia iwayomogi (Haninjin) from other Artemisia species. Specific primers based on RAPD results were designed to amplify a unique DNA marker for Haninjin. This allows for accurate identification of the medicinal plant used in traditional Korean medicine.

Phenolic Compounds Isolation: Researchers isolated phenolic compounds from Haninjin, including a new compound named iwayomin, and evaluated their effects on osteoblastic MC3T3-E1 cells. Compounds showed potential in stimulating bone formation, suggesting benefits in osteoporosis treatment.

Anti-inflammatory Effects: Haninjin exhibited anti-inflammatory effects in human gingival fibroblasts stimulated with LPS. It down-regulated genes activated by LPS and reduced the production of inflammatory mediators, implying comprehensive inhibitory effects on inflammation and immune response genes.

Peroxynitrite Scavenging: Methanolic extracts from Haninjin were tested for their ability to scavenge peroxynitrite (ONOO(-)), a harmful compound. Haninjin emerged as the most effective, with compounds like chlorogenic acid, genkwanin, and scopoletin showing strong scavenging activities.

Antibacterial Properties of Vulgarone B: Vulgarone B, derived from Haninjin essential oil, demonstrated significant inhibitory effects on antibiotic-resistant bacteria and potential as a natural antibacterial agent, especially when combined with oxacillin.

Lipid Metabolism Activation: An ethanol extract from Haninjin activated PPARδ, leading to increased expression of genes involved in fatty acid metabolism and reduced obesity in high-fat diet-fed mice, indicating potential as a functional food ingredient for managing hyperlipidemia and obesity.

Chemical Makeup of Essential Oil: GC and GC-MS analysis of Haninjin essential oil identified 85 compounds, with the main components being camphor, 1,8-cineole, and borneol. The oil showed antibacterial properties against various bacteria strains.

Immunomodulatory Effects: AIP1, a fraction from Haninjin, influenced the Fas/FasL-dependent apoptosis pathway in mouse thymocytes, suggesting immunomodulatory effects. A carbohydrate extract from Haninjin also suppressed dendritic cell activity, potentially reducing immune overreactions.

Anti-allergic Effects: A water-soluble carbohydrate from Haninjin, AIP1, significantly reduced symptoms of allergic asthma in mice. Furthermore, Artemisia iwayomogi extract (AIE) was shown to reduce mast cell-mediated allergic reactions by regulating intracellular calcium and pro-inflammatory cytokines.

Antifibrotic Effects: Haninjin displayed antifibrotic effects in liver fibrosis induced by various methods in rodents, suggesting potential as a therapeutic agent. It improved antioxidant activities and inhibited extracellular matrix protein production, thereby reducing liver fibrosis severity.

Hepatoprotective Effects: Haninjin extracts showed hepatoprotective properties against ethanol-induced liver damage in mice, enhancing liver antioxidant defenses and improving lipid metabolism. Moreover, Haninjin essential oil induced apoptotic cell death in human oral epidermoid carcinoma cells, highlighting its potential as a cancer chemopreventive agent.

References:

1. Multiplex PCR method to discriminate Artemisia iwayomogi from other Artemisia plants
2. Application of the multiplex PCR method for discrimination of Artemisia iwayomogi from other Artemisia herbs
3. Development of SCAR marker for discrimination of Artemisia princeps and A. argyi from other Artemisia herbs
4. Phenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cells
5. Anti-inflammatory changes of gene expression by Artemisia iwayomogi in the LPS-stimulated human gingival fibroblast: microarray analysis
6. Active components from Artemisia iwayomogi displaying ONOO(-) scavenging activity
7. Antibacterial effects of vulgarone B from Artemisia iwayomogi alone and in combination with oxacillin
8. An ethanol extract of Artemisia iwayomogi activates PPARδ leading to activation of fatty acid oxidation in skeletal muscle
9. Chemical composition and antibacterial activity of essential oil of Artemisia iwayomogi
10. AIP1, a water-soluble fraction from Artemisia iwayomogi, suppresses thymocyte apoptosis in vitro and down-regulates the expression of Fas gene
11. AIP1, a carbohydrate fraction from Artemisia iwayomogi, modulates the functional differentiation of bone marrow-derived dendritic cells
12. Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophages
13. Inhibitors of inducible nitric oxide synthase expression from Artemisia iwayomogi
14. The polysaccharide fraction AIP1 from Artemisia iwayomogi suppresses apoptotic death of the mouse spleen cells in culture
15. A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin
16. A carbohydrate fraction, AIP1 from Artemisia iwayomogi suppresses pulmonary eosinophilia and Th2-type cytokine production in an ovalbumin-induced allergic asthma. Down-regulation of TNF-alpha expression in the lung
17. Anti-allergic effects of Artemisia iwayomogi on mast cell-mediated allergy model
18. Artemisia iwayomogi inhibits immediate-type allergic reaction and inflammatory cytokine secretion
19. Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis
20. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice
21. RNA interference targeting Fas protects mice from fulminant hepatitis
22. Aqueous extract of Artemisia iwayomogi Kitamura attenuates cholestatic liver fibrosis in a rat model of bile duct ligation
23. Benefit of farnesoid X receptor inhibition in obstructive cholestasis
24. Antifibrotic effects of Artemisia capillaris and Artemisia iwayomogi in a carbon tetrachloride-induced chronic hepatic fibrosis animal model
25. The ethanol-soluble part of a hot-water extract from Artemisia iwayomogi inhibits liver fibrosis induced by carbon tetrachloride in rats
26. Amniotic membrane application reduces liver fibrosis in a bile duct ligation rat model
27. Comparative study of the hepatoprotective efficacy of Artemisia iwayomogi and Artemisia capillaris on ethanol-administered mice
28. MAPK activation is necessary to the apoptotic death of KB cells induced by the essential oil isolated from Artemisia iwayomogi

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