Hibiscus Macranthus: An Overview

1) Studied Conditions

Hibiscus macranthus has been studied for a variety of conditions, primarily focused on its effects on fertility and reproductive health. Research has also looked into its antioxidant properties and its potential impact on conditions related to oxidative stress.

2) Effectiveness in Treating Conditions

The efficacy of Hibiscus macranthus in treating the studied conditions is still a subject of scientific inquiry. While some studies suggest potential benefits, more rigorous and well-designed clinical trials are necessary to substantiate these claims and determine its effectiveness.

3) Health Benefits

• Antioxidant Effects: Hibiscus macranthus contains compounds that may exhibit antioxidant properties, helping to combat oxidative stress.
• Reproductive Health: There has been some indication that it may influence hormonal balance and fertility, although this is based on preliminary research.

4) Downsides

Like many herbal supplements, Hibiscus macranthus may have downsides, including potential side effects or interactions with medications. It is always recommended to consult with a healthcare provider before starting any new supplement regimen.

5) Impact on Genetic Variations

There is currently limited research on the relationship between Hibiscus macranthus and specific genetic variations. As genetics can influence an individual's response to certain compounds, further studies could provide insights into how genetic differences may affect the benefits or risks of taking Hibiscus macranthus.

Study Summary on Hibiscus Macranthus

Objective: Research on Hibiscus macranthus primarily focused on its potential androgenic effects and impact on male reproductive functions, with comparisons to Basella alba and other plant extracts.

Key Findings:

• In vitro Testosterone Production: Adult rat testes slices incubated with extracts from Hibiscus macranthus and Basella alba in DME/Ham F12 medium showed increased testosterone production. The androgenic activity was most pronounced in methylene chloride and methanol extracts.
• Leydig Cell Research: Basella alba extracts increased testosterone output in Leydig cells from both bull and rat testes, whereas Hibiscus macranthus did not exhibit androgenic effects and suppressed testosterone production at higher doses.
• Impact on Male Rats: Aqueous extracts from Hibiscus macranthus and Basella alba demonstrated anabolic and virilizing effects on mature male albino Wistar rats, enhancing body weight, seminal vesicle weight, sperm production, and testosterone levels.
• Effects on Female Rats: Oral aqueous extracts from Hibiscus macranthus and other plants increased the weight of ovaries and uterus in immature female rats and raised serum and ovarian estradiol levels.
• Ovarian Hormone Production: Plant mixture extracts, including Hibiscus macranthus, when combined with hCG, significantly increased the production of estradiol by rat ovarian cells.
• Reproductive Physiology: The plant extracts, containing Hibiscus macranthus, influenced reproductive physiology in young female rats, indicating the presence of estrogen-like compounds in the extracts.

Conclusions:

The studies concluded that Hibiscus macranthus extracts have varying effects on reproductive functions, with androgenic activity not being evident compared to Basella alba. However, the extracts from Hibiscus macranthus showed potential anabolic and virilizing effects on male rats and estrogen-like effects on female rat reproductive physiology. These findings suggest the plant's possible use in enhancing male reproductive health and its role in female reproductive regulation.

References:

1. Effects of extracts from Hibiscus macranthus and Basella alba mixture on testosterone production in vitro in adult rat testes slices
2. Effects of Basella alba and Hibiscus macranthus extracts on testosterone production of adult rat and bull Leydig cells
3. Effects of aqueous extracts of Hibiscus macranthus and Basella alba in mature rat testis function
4. Oestrogenicity and effect on hepatic metabolism of the aqueous extract of the leaf mixture of Aloe buettneri, Dicliptera verticillata, Hibiscus macranthus and Justicia insularis
5. Inductive effect of the leaf mixture extract of Aloe buettneri, Justicia insularis, Dicliptera verticillata and Hibiscus macranthus on in vitro production of estradiol
6. Effects of an aqueous extract of Aloe buettneri, Justicia insularis, Hibiscus macranthus, Dicliptera verticillata on some physiological and biochemical parameters of reproduction in immature female rats

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