Molybdenum

1. Conditions Molybdenum Has Been Studied For

Molybdenum has been studied in various contexts, primarily related to its role as an essential trace element in the human body. It is a vital component of several key enzymes, including sulfite oxidase, xanthine oxidase, and aldehyde oxidase, which are involved in the metabolism of sulfur amino acids, purines, and pyrimidines. Conditions for which molybdenum has been studied include:

• Molybdenum cofactor deficiency
• Gout
• Certain types of cancers
• Metabolic disorders

2. Efficacy in Treating Conditions

Molybdenum is essential for normal health, but there is limited evidence on its efficacy in treating specific conditions. It is crucial for individuals with molybdenum cofactor deficiency, a rare genetic condition. Supplementation can be lifesaving in such cases. However, for other conditions, such as gout and cancer, the evidence is inconclusive and more research is needed to determine its therapeutic potential.

3. Health Benefits of Molybdenum

As an essential trace element, molybdenum contributes to various health benefits:

• Enables the body to process proteins and genetic material (DNA).
• Helps break down harmful sulfites and prevents toxins from building up in the body.
• May contribute to normal growth and development.

4. Potential Downsides of Molybdenum

While molybdenum is generally safe when consumed in amounts typically found in food, there are potential downsides associated with excessive intake:

• High levels of molybdenum can interfere with the body's uptake of copper, potentially leading to copper deficiency.
• Excessive supplementation may cause symptoms like gout, diarrhea, and anemia.
• Occupational exposure to molybdenum dust or fumes can lead to lung irritation or other respiratory issues.

5. Molybdenum and Genetic Variations

Individuals with certain genetic variations may experience different effects from molybdenum:

• People with mutations in genes for molybdenum cofactor production or metabolism may require molybdenum supplementation to prevent or treat molybdenum cofactor deficiency.
• Some genetic variations may affect how well an individual can metabolize substances that require molybdenum-dependent enzymes.

It is important to note that genetic variations can impact how individuals respond to nutrients, and personalized medical advice should be sought in such cases.

Molybdenum: An Essential Trace Element

Molybdenum is a vital trace element present in many foods, especially legumes, dairy, and meats. It is a key part of a molybdenum cofactor that is essential for the function of enzymes such as xanthine oxidase, aldehyde oxidase, and sulfite oxidase, which are involved in purine metabolism, conversion of aldehydes to acids, and metabolizing sulfur-containing amino acids respectively.

Deficiency in molybdenum is uncommon but can occur in cases like long-term total parenteral nutrition, leading to symptoms like tachycardia and mental disturbances. Inherited deficiencies can cause severe health problems, including neurological issues and increased cancer risk. Molybdenum deficiency in soil may contribute to higher risks of esophageal cancer due to reduced enzyme activity for detoxifying substances.

Research has measured molybdenum levels in food items, estimating daily intake and identifying food sources of this trace element. Studies suggest that average daily dietary intake of molybdenum in the U.S. is between 120 to 240 micrograms, with variations based on demographic factors.

Other studies have looked at the relationship between drinking water composition and cardiovascular disease, with findings indicating an inverse relationship between water hardness, calcium levels, and cardiovascular mortality rates. Molybdenum levels in human serum have been measured to assess its presence in the body and to understand the role of dietary intake in plasma molybdenum levels.

Excess or deficiency in trace elements like molybdenum can lead to health issues, and proper techniques for sample collection and analysis are crucial for accurate assessment. Research also suggests that treating the primary disorder causing the trace element imbalance is vital for recovery.

Conclusion

Molybdenum plays a crucial role in human health as part of several enzymes. While deficiency is rare, it can lead to serious health issues. Understanding dietary intake and the impact of molybdenum levels in various biological functions continues to be an important area of study.

References:

1. Molybdenum: an essential trace element
2. Molybdenum, nickel, cobalt, vanadium, and strontium in total diets
3. The analysis of copper, selenium, and molybdenum contents in frequently consumed foods and an estimation of their daily intake in korean adults
4. Preliminary report on nationwide study of drinking water and cardiovascular diseases
5. Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc
6. The role of copper, molybdenum, selenium, and zinc in nutrition and health
7. Identification of the xanthine oxidase factor as molybdenum
8. Hepatic sulfite oxidase. Identification of the molybdenum center as the site of irreversible inactivation by ferricyanide
9. Studies on metalloflavoproteins. III. Aldehyde oxidase: a molybdoflavoprotein
10. Hereditary xanthinuria: report of two cases
11. Asymptomatic hereditary xanthinuria: a case report
12. Molybdenum-cofactor-containing enzymes: structure and mechanism
13. Molybdenum in the diet: an estimate of average daily intake in the United States
14. Molecular basis of the biological function of molybdenum. Effect of tungsten on xanthine oxidase and sulfite oxidase in the rat
15. Molecular basis of the biological function of molybdenum: the relationship between sulfite oxidase and the acute toxicity of bisulfite and SO2
16. Amino acid intolerance during prolonged total parenteral nutrition reversed by molybdate therapy
17. Molybdenum absorption, excretion, and retention studied with stable isotopes in young men at five intakes of dietary molybdenum
18. Molybdenum absorption, excretion, and retention studied with stable isotopes in young men during depletion and repletion
19. Selenium, molybdenum, and vanadium in human blood
20. Determination of molybdenum in human serum by neutron activation analysis
21. Plasma molybdenum reflects dietary molybdenum intake
22. Trace elements status in diabetes mellitus type 2: possible role of the interaction between molybdenum and copper in the progress of typical complications
23. Reference values for trace and ultratrace elements in human serum determined by double-focusing ICP-MS
24. Molybdenum--is it an essential trace metal?
25. 90-Day subchronic toxicity study of sodium molybdate dihydrate in rats
26. Clinical studies on molybdenum in patients requiring long-term hemodialysis
27. Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum
28. Mild renal failure induced by subchronic exposure to molybdenum: urinary kallikrein excretion as a marker of distal tubular effect
29. Cellular mechanisms of toxicity and tolerance in the copper-loaded rat. III. Ultrastructural changes and copper localization in the kidney
30. A case report of acute human molybdenum toxicity from a dietary molybdenum supplement--a new member of the "Lucor metallicum" family

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