Moringa: Overview of Health Aspects

1) Conditions Studied

Moringa oleifera, commonly known as Moringa, has been studied for various health conditions. These include:

• Diabetes
• High blood pressure
• Inflammation
• Malnutrition
• Anemia
• Asthma
• Arthritis
• Gastrointestinal disorders

2) Effectiveness in Treating Conditions

While Moringa has been traditionally used in various cultures for its medicinal properties, scientific evidence varies in quality. Some studies suggest it may be beneficial in:

• Lowering blood sugar levels in diabetic patients
• Reducing high blood pressure
• Decreasing inflammation

However, more rigorous scientific research and clinical trials are needed to confirm these effects and establish proper dosages.

3) Health Benefits

Moringa is known for its nutritional value and health benefits, which include:

• Rich in vitamins, minerals, and amino acids
• Antioxidant properties that may protect against cell damage
• Potential to support immune function
• May improve digestive health

4) Downsides

While Moringa is generally considered safe when consumed in food amounts, it may have downsides when taken in large doses or as a supplement:

• Potential side effects include nausea, diarrhea, and heartburn
• May interact with certain medications, such as those for thyroid or diabetes
• Parts of the plant may contain compounds that could be harmful with long-term use

5) Genetic Variations

There is limited research on the interaction between Moringa and specific genetic variations. Some studies suggest that genetic differences could influence the efficacy and safety of herbal supplements, including Moringa. However, at present, no specific genetic contraindications or benefits have been well-established in the scientific literature for Moringa.

Moringa Oleifera: A Potential Antidiabetic and Antioxidant Agent

Diabetes and Hyperglycemia Treatment: Moringa oleifera leaf extract has demonstrated efficacy in reducing blood sugar levels, supporting its traditional medicinal use for treating diabetes. Studies on rats with hyperglycemia have shown significant reductions in fasting blood glucose and postprandial glucose levels following treatment with the extract.

Antioxidant Activity: Moringa oleifera exhibits potent antioxidant capabilities, as observed in studies conducted in Taiwan. The plant's extracts, especially from methanol, have shown strong abilities to neutralize radicals and exhibit high Superoxide Dismutase (SOD) activity. The leaf extract, in particular, was noted for its high antioxidant activity.

Genetic Diversity and Breeding: Research on the genetic diversity of Moringa oleifera genotypes has revealed considerable variation, which is crucial for effective breeding programs. The identification of specific genotypes as potential parents for future breeding suggests opportunities for cultivating plants with desired traits.

Seasonal Influence on Chemical Makeup: The chemical composition and antioxidant activity of Moringa oleifera vary with seasons, with winter samples generally showing higher levels of beneficial compounds compared to summer samples.

Potential in Traditional Medicine: Traditional use of medicinal plants, including Moringa oleifera, remains vital in regions like Batan Island in the Philippines. The plant is utilized for treating circulatory and genitourinary system diseases, demonstrating its significance in local healthcare.

Neuroprotective and Anticonvulsant Effects: Moringa oleifera leaf extract has shown potential neuroprotective and anticonvulsant effects, aligning with traditional uses for treating epilepsy and neurological disorders.

Larvicidal and Pupicidal Activity: Methanolic seed extracts from Moringa oleifera have shown effectiveness in killing larvae and pupae of Anopheles stephensi, a vector for malaria, suggesting potential uses in mosquito vector control.

Protease Inhibition: Moringa oleifera contains protease inhibitors which inhibit several significant proteases, with potential applications in therapeutic drug development and as a preservative in the seafood industry.

Nutritional Intervention: While Moringa oleifera leaves are promoted for their nutritional benefits, especially in addressing under-nutrition, scientific validation of its efficacy is needed.

References:

1. Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats
2. Genetic dissection of new genotypes of drumstick tree (Moringa oleifera Lam.) using random amplified polymorphic DNA marker
3. Effect of different parts (leaf, stem and stalk) and seasons (summer and winter) on the chemical compositions and antioxidant activity of Moringa oleifera
4. Use of weeds as traditional vegetables in Shurugwi District, Zimbabwe
5. An ethnobotanical study of medicinal plants and traditional therapies on Batan Island, the Philippines
6. Studies on neuropharmacological profile of ethanol extract of Moringa oleifera leaves in mice
7. Experimental Assessment of Moringa oleifera Leaf and Fruit for Its Antistress, Antioxidant, and Scavenging Potential Using In Vitro and In Vivo Assays
8. Energy and micronutrient composition of dietary and medicinal wild plants consumed during drought. Study of rural Fulani, northeastern Nigeria
9. Abortifacient activity of a medicinal plant "moringa oleifera" in rats
10. Quality of cooked ground buffalo meat treated with the crude extracts of Moringa oleifera (Lam.) leaves
11. Protease inhibitor from Moringa oleifera with potential for use as therapeutic drug and as seafood preservative
12. Adoption of Moringa oleifera to combat under-nutrition viewed through the lens of the "Diffusion of innovations" theory
13. Larvicidal and repellent potential of Moringa oleifera against malarial vector, Anopheles stephensi Liston (Insecta: Diptera: Culicidae)
14. Bio-sorption of atrazine in the press-cake from oilseeds
15. Removal of sodium lauryl sulphate by coagulation/flocculation with Moringa oleifera seed extract
16. Removal of BTEX from aqueous solution using Moringa oleifera seed cake
17. Anti-cyanobacterial activity of Moringa oleifera seeds
18. Analgesic effects of methanolic extracts of the leaf or root of Moringa oleifera on complete Freund's adjuvant-induced arthritis in rats
19. [Contribution to the study of the anti-inflammatory activity of Moringa oleifera (moringaceae)]
20. Ethnobotanical survey of medicinal plants used by Bapedi healers to treat diabetes mellitus in the Limpopo Province, South Africa
21. Moringa oleifera Lam.: Protease activity against blood coagulation cascade
22. Documentation and quantitative analysis of the local knowledge on medicinal plants among traditional Siddha healers in Virudhunagar district of Tamil Nadu, India
23. Fruit pod extracts as a source of nutraceuticals and pharmaceuticals
24. Estimation of total phenolic content, in-vitro antioxidant and anti-inflammatory activity of flowers of Moringa oleifera
25. Antioxidant activity of Moringa oleifera tissue extracts
26. Caseinolytic and milk-clotting activities from Moringa oleifera flowers
27. A novel chitin-binding protein from Moringa oleifera seed with potential for plant disease control
28. Purification of a chitin-binding protein from Moringa oleifera seeds with potential to relieve pain and inflammation
29. Purification and characterization of a class II α-Mannosidase from Moringa oleifera seed kernels
30. Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2'-O-acetyl-α-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera
31. Antimicrobial isothiocyanates from the seeds of Moringa oleifera Lam
32. Development of a reliable extraction and quantification method for glucosinolates in Moringa oleifera
33. Effects of oral administration of benzylamine on glucose tolerance and lipid metabolism in rats
34. Hypotensive constituents from the pods of Moringa oleifera
35. Cardioprotective potential of N,α-L-rhamnopyranosyl vincosamide, an indole alkaloid, isolated from the leaves of Moringa oleifera in isoproterenol induced cardiotoxic rats: in vivo and in vitro studies
36. Unusual glycosides of pyrrole alkaloid and 4'-hydroxyphenylethanamide from leaves of Moringa oleifera
37. Isolation and structure elucidation of new nitrile and mustard oil glycosides from Moringa oleifera and their effect on blood pressure
38. Pterygospermin; the antibacterial principle of Moringa pterygosperma, Gaertn
39. Antibiotic principle from Moringa pterygosperma. VI. Mechanism of antibacterial action of pterygospermin inhibition of transaminase by pterygospermin
40. Simultaneous HPLC quantitative analysis of active compounds in leaves of Moringa oleifera Lam
41. Simultaneous Determination of Crypto-Chlorogenic Acid, Isoquercetin, and Astragalin Contents in Moringa oleifera Leaf Extracts by TLC-Densitometric Method
42. Molecular imprinted polymer for solid-phase extraction of flavonol aglycones from Moringa oleifera extracts
43. Antiproliferation and induction of apoptosis by Moringa oleifera leaf extract on human cancer cells
44. Simultaneous determination of quercetin, rutin and kaempferol in the leaf extracts of Moringa oleifera Lam. and Raphinus sativus Linn. by liquid chromatography-tandem mass spectrometry
45. New α-glucosides of caffeoyl quinic acid from the leaves of Moringa oleifera Lam
46. Nigerian foodstuffs with prostate cancer chemopreventive polyphenols
47. Optimization of extraction conditions for the extraction of phenolic compounds from Moringa oleifera leaves
48. Hydrogen sulfide mediates the anti-survival effect of sulforaphane on human prostate cancer cells
49. Cultivar effect on Moringa oleifera glucosinolate content and taste: a pilot study
50. Studies on gum of Moringa oleifera for its emulsifying properties
51. Influence of Moringa oleifera on pharmacokinetic disposition of rifampicin using HPLC-PDA method: a pre-clinical study
52. Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol
53. Toxicological evaluation of the aqueous leaf extract of Moringa oleifera Lam. (Moringaceae)
54. Alteration of brain monoamines & EEG wave pattern in rat model of Alzheimer's disease & protection by Moringa oleifera
55. Effect of plant extracts on Alzheimer's disease: An insight into therapeutic avenues
56. Alpha-glucosidase inhibitory activity and lipid-lowering mechanisms of Moringa oleifera leaf extract
57. Fully acetylated carbamate and hypotensive thiocarbamate glycosides from Moringa oleifera
58. Attenuation of the extract from Moringa oleifera on monocrotaline-induced pulmonary hypertension in rats
59. Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review
60. Novel drug delivery system of plant extract for the management of diabetes: an antidiabetic study
61. Effect of Moringa oleifera bark extracts on dexamethasone-induced insulin resistance in rats
62. Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes
63. Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms
64. Benzyl isothiocyanate exhibits anti-inflammatory effects in murine macrophages and in mouse skin
65. Moringa oleifera pod inhibits inflammatory mediator production by lipopolysaccharide-stimulated RAW 264.7 murine macrophage cell lines
66. Cyclophosphamide-induced neutropenia: effect on postischemic skin-flap survival
67. Immunomodulatory activity of methanolic leaf extract of Moringa oleifera in animals
68. Immunomodulatory effect of Moringa oleifera Lam. extract on cyclophosphamide induced toxicity in mice
69. Adsorption of the cyanobacterial hepatotoxin microcystin-LR by a low-cost activated carbon from the seed husks of the pan-tropical tree, Moringa oleifera
70. Inhibitory effects of crude extracts from some edible Thai plants against replication of hepatitis B virus and human liver cancer cells
71. Antiradical efficiency of 20 selected medicinal plants
72. Role of Moringa oleifera in regulation of diabetes-induced oxidative stress
73. Role of oxidative stress in development of cardiovascular complications in diabetes mellitus
74. The role of antioxidants in the pathophysiology, complications, and management of diabetes mellitus
75. Role of Moringa oleifera leaf extract in the regulation of thyroid hormone status in adult male and female rats
76. Retinoprotective effects of Moringa oleifera via antioxidant, anti-inflammatory, and anti-angiogenic mechanisms in streptozotocin-induced diabetic rats
77. Antiasthmatic activity of Moringa oleifera Lam: A clinical study
78. Investigation into the mechanism of anti-asthmatic action of Moringa oleifera
79. Effect of Moringa oleifera Lam. seed extract on ovalbumin-induced airway inflammation in guinea pigs
80. Histochemical reactions of the enterochromaffin cells and the 5-hydroxytryptamine content of the mammalian duodenum
81. Role of Moringa oleifera on enterochromaffin cell count and serotonin content of experimental ulcer model
82. Moringa oleifera induced potentiation of serotonin release by 5-HT(3) receptors in experimental ulcer model
83. Assessment of the antiulcer potential of Moringa oleifera root-bark extract in rats
84. Pharmacologic properties of Moringa oleifera. 2: Screening for antispasmodic, antiinflammatory and diuretic activity
85. Potential of Moringa oleifera root and Citrus sinensis fruit rind extracts in the treatment of ulcerative colitis in mice
86. Anti-inflammatory effect of Moringa oleifera Lam. seeds on acetic acid-induced acute colitis in rats
87. Renoprotective effects of Moringa oleifera pods in 7,12-dimethylbenz [a] anthracene-exposed mice
88. Protective effect of Moringa oleifera leaves against gentamicin-induced nephrotoxicity in rabbits
89. Chemopreventive efficacy of Moringa oleifera pods against 7, 12-dimethylbenz[a]anthracene induced hepatic carcinogenesis in mice
90. Antioxidant action of Moringa oleifera Lam. (drumstick) against antitubercular drugs induced lipid peroxidation in rats
91. Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level
92. Therapeutic potential of Moringa oleifera extracts against acetaminophen-induced hepatotoxicity in rats
93. Moringa oleifera hydroethanolic extracts effectively alleviate acetaminophen-induced hepatotoxicity in experimental rats through their antioxidant nature
94. Edible oils for liver protection: hepatoprotective potentiality of Moringa oleifera seed oil against chemical-induced hepatitis in rats
95. Moringa oleifera Lam. leaf extract prevents early liver injury and restores antioxidant status in mice fed with high-fat diet
96. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it
97. Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice
98. Amelioration of ionizing radiation induced lipid peroxidation in mouse liver by Moringa oleifera Lam. leaf extract
99. Leaf extract of Moringa oleifera prevents ionizing radiation-induced oxidative stress in mice
100. Antioxidant extracts of African medicinal plants induce cell cycle arrest and differentiation in B16F10 melanoma cells
101. HeLa cultures defined
102. Moringa Oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells
103. The role of nuclear factor kappaB in pancreatic cancer and the clinical applications of targeted therapy
104. Suppressive effects of Moringa oleifera Lam pod against mouse colon carcinogenesis induced by azoxymethane and dextran sodium sulfate
105. Matrix metalloproteinases and cellular fibrinolytic activity
106. Enhancement of human skin facial revitalization by moringa leaf extract cream
107. Larvicidal activity of the water extract of Moringa oleifera seeds against Aedes aegypti and its toxicity upon laboratory animals
108. Toxicity potentials of the nutraceutical Moringa oleifera at supra-supplementation levels
109. Toxicological evaluations of methanolic extract of Moringa oleifera leaves in liver and kidney of male Wistar rats
110. Phytochemical screening and toxicity studies on the methanol extract of the seeds of moringa oleifera
111. Genotoxicity evaluation of Moringa oleifera seed extract and lectin

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