Olive Leaf Extract Overview

1) Studied Conditions

Olive leaf extract has been studied for a variety of conditions including:

• Cardiovascular diseases such as hypertension (high blood pressure)
• Diabetes and related metabolic disorders
• Antibacterial and antiviral properties, including potential effects on influenza and the common cold
• Antioxidant properties
• Anti-inflammatory effects
• Immune system support

2) Efficacy in Treating Conditions

While some studies suggest olive leaf extract may have beneficial effects, the evidence is not conclusive. For example:

• There is some evidence that olive leaf extract can help lower blood pressure in people with hypertension.
• It may have positive effects on blood sugar regulation, which could benefit those with diabetes.
• Its antibacterial and antiviral properties have been observed in laboratory settings, but more research is needed to confirm these effects in humans.

3) Health Benefits

Olive leaf extract may offer several health benefits, including:

• Lowering blood pressure and improving cardiovascular health
• Supporting glucose metabolism and potentially aiding in diabetes management
• Possessing antimicrobial properties that could help fight certain infections
• Providing antioxidants that protect cells from damage
• Reducing inflammation, which is beneficial for a range of inflammatory conditions

4) Downsides

While olive leaf extract is generally considered safe for most people, some potential downsides include:

• Allergic reactions in individuals allergic to olives or olive products
• Possible interaction with certain medications, particularly blood pressure and diabetes drugs
• Mild side effects in some individuals, such as dizziness, headache, or stomach upset

5) Genetic Variations

Currently, there's limited research on the interaction between olive leaf extract and specific genetic variations. However, it's always possible that individual genetic differences could influence how one responds to any herbal supplement, including olive leaf extract. If you have concerns about genetic compatibility with supplements, consult a healthcare professional who can provide personalized advice based on your genetic profile.

Olive Leaf Extract for Hypertension and Health

A clinical study revealed that Olive (Olea europaea) leaf extract is as effective as the anti-hypertensive drug Captopril in reducing systolic and diastolic blood pressure in stage-1 hypertension patients. The extract also improved lipid profiles, particularly triglycerides.

Further research highlights the benefits of olive leaf extracts rich in oleanolic acid, which have shown to prevent hypertension, atherosclerosis, and improve insulin resistance in rats, suggesting benefits for populations with salt-sensitive hypertension.

Studies on oleuropein, a phenolic compound in olives, indicate its diverse pharmacological properties including antioxidant, anti-inflammatory, and lipid-lowering effects. These properties may contribute to the Mediterranean diet's health benefits.

In middle-aged overweight men, olive leaf polyphenols significantly enhanced insulin sensitivity and pancreatic β-cell responsiveness, indicating potential benefits for metabolic syndrome risk.

Secoiridoid glycosides from olive leaves have been identified as potent inhibitors of the angiotensin converting enzyme (ACE), which regulates blood pressure. Olive leaf extract EFLA943 was shown to lower blood pressure and cholesterol levels in humans with borderline hypertension.

Additionally, olive leaf extracts rich in polyphenols like oleuropein counteracted the negative health effects of a high-carbohydrate, high-fat diet in rats, except for persistent high blood pressure.

The safety of maslinic acid, found in olive skin, was confirmed in mice, indicating its potential as a nutraceutical.

Olive leaf's pentacyclic triterpenoids have been suggested to have therapeutic potential for diabetes and related complications due to their biological activities affecting glucose absorption, insulin secretion, and protection against vascular issues.

Analyses using HPLC-ESI-QTOF-MS and electrospray ionisation mass spectrometry (ESI-MS) have provided comprehensive insights into the phenolic compounds in olive-leaf extracts, supporting their use as natural antioxidants.

Lastly, the study of the Nocellara del Belice cultivar revealed a new component, aromadendrine, with potent anti-inflammatory effects, and confirmed the health-promoting properties of olive leaves, including antioxidant and antihypertensive effects.

References:

1. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril
2. Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves
3. Oleuropein in olive and its pharmacological effects
4. Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial
5. Isolation of an angiotensin converting enzyme (ACE) inhibitor from Olea europaea and Olea lancea
6. Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins
7. Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats
8. Assessment of the safety of maslinic acid, a bioactive compound from Olea europaea L
9. The pentacyclic triterpenoids in herbal medicines and their pharmacological activities in diabetes and diabetic complications
10. HPLC-ESI-QTOF-MS as a powerful analytical tool for characterising phenolic compounds in olive-leaf extracts
11. Aromadendrine, a new component of the flavonoid pattern of Olea europaea L. and its anti-inflammatory activity
12. Olive tree (Olea europaea) leaves: potential beneficial effects on human health
13. Chlorophyll and carotenoid patterns in olive fruits, Olea europaea Cv. arbequina
14. Liquid chromatography with electrospray ionisation mass spectrometric detection of phenolic compounds from Olea europaea
15. Rapid and complete extraction of phenols from olive oil and determination by means of a coulometric electrode array system
16. Antioxidant effect of two virgin olive oils depends on the concentration and composition of minor polar compounds
17. Acid hydrolysis of secoiridoid aglycons during storage of virgin olive oil
18. Identification of lignans as major components in the phenolic fraction of olive oil
19. Dynamic ultrasound-assisted extraction of oleuropein and related biophenols from olive leaves
20. Major phenolic compounds in olive oil: metabolism and health effects
21. Nondestructive evaluation of anthocyanins in olive (Olea europaea) fruits by in situ chlorophyll fluorescence spectroscopy
22. Biochemical characterization of a lipase from olive fruit (Olea europaea L.)
23. Genome-wide identification of alternate bearing-associated microRNAs (miRNAs) in olive (Olea europaea L.)
24. Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma
25. Transport mechanism and metabolism of olive oil hydroxytyrosol in Caco-2 cells
26. Olive oil phenolics are dose-dependently absorbed in humans
27. Olive oil phenols are absorbed in humans
28. The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation
29. Hydrolysis of Oleuropein by Lactobacillus plantarum Strains Associated with Olive Fermentation
30. Absorption and metabolism of olive oil secoiridoids in the small intestine
31. Simultaneous determination of oleuropein and hydroxytyrosol in rat plasma using liquid chromatography with fluorescence detection
32. Liquid chromatography-tandem mass spectrometry analysis of oleuropein and its metabolite hydroxytyrosol in rat plasma and urine after oral administration
33. Effects of olive polyphenols administration on nerve growth factor and brain-derived neurotrophic factor in the mouse brain
34. NOX1/NADPH oxidase negatively regulates nerve growth factor-induced neurite outgrowth
35. Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species
36. Inhibition of 6-hydroxydopamine-induced PC12 cell apoptosis by olive (Olea europaea L.) leaf extract is performed by its main component oleuropein
37. Olive (Olea europaea L.) leaf extract attenuates early diabetic neuropathic pain through prevention of high glucose-induced apoptosis: in vitro and in vivo studies
38. Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats
39. Effects on rats of aqueous extracts of plants used in folk medicine as antihypertensive agents
40. Changes in the phenolic content of low density lipoprotein after olive oil consumption in men. A randomized crossover controlled trial
41. The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial
42. Effects of differing phenolic content in dietary olive oils on lipids and LDL oxidation--a randomized controlled trial
43. New insights into controversies on the antioxidant potential of the olive oil antioxidant hydroxytyrosol
44. Effects of dietary factors on oxidation of low-density lipoprotein particles
45. Antioxidant activity of olive polyphenols in humans: a review
46. Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans
47. Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial
48. Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men
49. Antiatherogenic components of olive oil
50. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals
51. Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans
52. Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea
53. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
54. Metabolism: bile acids heat things up
55. Effect of freeze dried extract of Olea europaea on the pituitary-thyroid axis in rats
56. Extra virgin olive oil increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats
57. Oleuropein supplementation increases urinary noradrenaline and testicular testosterone levels and decreases plasma corticosterone level in rats fed high-protein diet
58. Specificity of the antiviral agent calcium elenolate
59. In vitro antiviral activity of calcium elenolate
60. Antibacterial activity in spices and local medicinal plants against clinical isolates of Karachi, Pakistan
61. Antimicrobial activity of commercial Olea europaea (olive) leaf extract
62. In vitro antimicrobial activity of olive leaves
63. Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract
64. Antiviral activity of calcium elenolate on parainfluenza infection of hamsters
65. An evaluation of the inhibitory effects against rotavirus infection of edible plant extracts
66. The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV)
67. Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment
68. Biological effects of hydroxytyrosol, a polyphenol from olive oil endowed with antioxidant activity
69. Antioxidant and other biological activities of phenols from olives and olive oil
70. Biophenols in table olives
71. Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid
72. Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats
73. Dried leaf extract of Olea europaea ameliorates islet-directed autoimmunity in mice
74. Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats
75. Antidiabetic effect of Olea europaea L. in normal and diabetic rats
76. Ethnopharmacological notes about ancient uses of medicinal plants in Trás-os-Montes (northern of Portugal)
77. Preliminary comparative analysis of medicinal plants used in the traditional medicine of Bulgaria and Italy
78. Wound repair potential of Olea europaea L. leaf extracts revealed by in vivo experimental models and comparative evaluation of the extracts' antioxidant activity
79. Efficacy of oleuropein against UVB irradiation: preliminary evaluation
80. Effects of olive leaf extract and its main component oleuroepin on acute ultraviolet B irradiation-induced skin changes in C57BL/6J mice
81. Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice
82. Olive (Olea europaea L.) leaf extract counteracts genotoxicity and oxidative stress of permethrin in human lymphocytes
83. Olea europaea leaf extract alters microRNA expression in human glioblastoma cells
84. Induction of growth inhibition and differentiation of human leukemia HL-60 cells by a Tunisian gerboui olive leaf extract
85. The antioxidant and anti-proliferative activity of the Lebanese Olea europaea extract
86. (2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells
87. Multiple antimelanoma potential of dry olive leaf extract
88. An allergen from Olea europaea pollen (Ole e 7) is associated with plant-derived food anaphylaxis
89. Clinical role of a lipid transfer protein that acts as a new apple-specific allergen
90. A non-allergenic Ole e 1-like protein from birch pollen as a tool to design hypoallergenic vaccine candidates
91. Bet v 1, the major birch pollen allergen, and Mal d 1, the major apple allergen, cross-react at the level of allergen-specific T helper cells
92. Effects of birch pollen-specific immunotherapy on apple allergy in birch pollen-hypersensitive patients
93. Birch-apple syndrome treated with birch pollen immunotherapy

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