Understanding Perilla: A Comprehensive Overview

1) Conditions Studied for Perilla's Effects

Perilla has been studied for a variety of health conditions, including:

• Allergic reactions (e.g., asthma, allergies)
• Inflammatory diseases
• Cardiovascular conditions
• Anxiety and depression
• Antioxidant properties
• Antimicrobial effects

2) Effectiveness in Treating Conditions

Research on the effectiveness of perilla for treating various conditions is ongoing. Some studies suggest that it may have beneficial effects due to its anti-inflammatory and antioxidant properties. However, more rigorous clinical trials are needed to conclusively determine its efficacy. It's always recommended to consult with a healthcare professional before using perilla as a treatment.

3) Health Benefits of Perilla

Perilla is associated with several potential health benefits, including:

• Reduction of inflammation
• Alleviation of allergy symptoms
• Improvement in cardiovascular health
• Enhancement of cognitive function
• Possessing antimicrobial properties

4) Potential Downsides of Perilla

While perilla is generally considered safe, it may have some downsides, including:

• Potential for allergic reactions in some individuals
• Unknown long-term safety profile
• Interaction with certain medications
• Limited availability in some regions

It is important to note that the safety of perilla during pregnancy and breastfeeding is not well-established, and caution is advised.

5) Perilla's Impact on Genetic Variations

Current research on how perilla may affect individuals with specific genetic variations is limited. Some evidence suggests that genetic factors can influence how one might respond to herbal supplements, including perilla. However, more studies are needed to determine its benefits or harms concerning particular genetic makeups. Always consult a healthcare provider for personalized advice.

Impact of Roasting Conditions on Perilla Oil Properties

Research has studied how roasting temperatures and durations influence the characteristics of perilla oil, which is rich in omega-3 fatty acids. Higher roasting temperatures and longer times result in darker oil, increased fluorescence, and a higher content of volatile compounds that impact flavor. The roasting process can be optimized for desired oil properties in industrial food production.

Perilla and Depression-Like Behaviors

The essential oil of Perilla frutescens (EOPF) was tested for its effects on mice with depression-like behaviors induced by stress. EOPF improved symptoms and increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus, suggesting potential antidepressant effects.

Bioavailability of Alpha-Linolenic Acid from Perilla Seed Oil

The bioavailability of alpha-linolenic acid (ALA) from perilla seed oil was examined. Enteric-coating was found to enhance plasma ALA levels after 24 hours, which may improve the benefits of long-term ALA supplementation from perilla seed oil.

Nutritional Composition and Health Benefits of Perilla Seeds

Perilla seeds contain high levels of polyunsaturated fatty acids, including omega-3 alpha-linolenic acid (ALA), which offers various health benefits, such as reducing the risk of cardiovascular diseases and inflammatory conditions.

Perilla Leaves and Anti-Nephritic Properties

A study identified compounds in perilla leaves that inhibit the proliferation of murine mesangial cells, which could contribute to the treatment of glomerulonephritis, particularly IgA nephropathy. Rosmarinic acid was suggested to have the primary anti-proliferative effect.

Antioxidant Activity of Korean Perilla Cultivars

Seeds from various Korean perilla cultivars exhibited strong antioxidant activity, which was directly related to their phenolic content. The study provides insight into the antioxidant properties of perilla seeds, which vary among cultivars.

Roasting's Effect on Pyrazines in Perilla Seed Oils

A new method was established to analyze pyrazines in perilla seed oils, with roasting found to significantly influence the types and quantities present, affecting the oil's flavor profile.

Autoxidation and Tocopherol Stability in Perilla Oil

Perilla oil was found to be more prone to oxidation than corn oil, but its tocopherols were more stable due to the presence of polyphenols, requiring stricter temperature control to prevent oxidation.

Perilla Oil's Effect on Blood Lipid Levels

Perilla oil treatment improved serum lipid levels and endothelial cell function in patients with hyperlipidemia, suggesting its safety and efficacy for clinical use.

References:

1. Effects of roasting conditions on the physicochemical properties and volatile distribution in perilla oils (Perilla frutescens var. japonica)
2. Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice
3. Bioavailability of omega-3 essential fatty acids from perilla seed oil
4. Health effects of omega-3,6,9 fatty acids: Perilla frutescens is a good example of plant oils
5. Inhibitory effect of decoction of Perilla frutescens on cultured murine mesangial cell proliferation and quantitative analysis of its active constituents
6. Identification, characterisation, and quantification of phenolic compounds in the antioxidant activity-containing fraction from the seeds of Korean perilla (Perilla frutescens) cultivars
7. Headspace-solid phase microextraction-gas chromatography-tandem mass spectrometry (HS-SPME-GC-MS2) method for the determination of pyrazines in perilla seed oils: impact of roasting on the pyrazines in perilla seed oils
8. Temperature dependence of autoxidation of perilla oil and tocopherol degradation
9. Formation of lipid oxidation and isomerization products during processing of nuts and sesame seeds
10. Effects of roasting on pyrazine contents and oxidative stability of red pepper seed oil prior to its extraction
11. Perilla oil and exercise decrease expressions of tumor necrosis factor-alpha, plasminogen activator inhibitor-1 and highly sensitive C-reactive protein in patients with hyperlipidemia
12. The fibrinolytic enzyme system and its role in the etiology of thromboembolic disease
13. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes
14. Effect of C-reactive protein on platelet-activating factor-induced platelet aggregation and membrane stabilization
15. Coronary C-reactive protein distribution: its relation to development of atherosclerosis
16. Physiology of the mesangial cell
17. Inhibitory effect of Perilla frutescens and its phenolic constituents on cultured murine mesangial cell proliferation
18. Dietary Perilla seed oil supplement increases plasma omega-3 polyunsaturated fatty acids and ameliorates immunoglobulin A nephropathy in high immunoglobulin A strain of ddY mice
19. Suppressive effects of Perilla frutescens on spontaneous IgA nephropathy in ddY mice
20. Enhanced production of glomerular extracellular matrix in a new mouse strain of high serum IgA ddY mice
21. Selective breeding for high serum IgA levels from noninbred ddY mice: isolation of a strain with an early onset of glomerular IgA deposition
22. Increased frequency of surface IgA-positive plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA (HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA

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