Reishi Mushroom (Ganoderma lucidum)

1) Conditions Studied

Reishi mushrooms have been studied for their potential effects on several conditions, including:

• Immune system enhancement
• Cancer
• Cardiovascular diseases
• Diabetes
• Liver disease
• Chronic fatigue syndrome
• Anxiety and depression

2) Efficacy in Treating Conditions

While some studies suggest potential health benefits, the evidence is not conclusive, and more research is required to determine the efficacy of Reishi mushrooms in treating these conditions. The FDA has not approved Reishi for the treatment of any medical condition.

3) Health Benefits

Reported health benefits of Reishi mushrooms include:

• Boosting the immune system
• Potential anti-cancer properties
• Reducing stress and improving sleep
• Antioxidant effects
• Lowering blood pressure and cholesterol

4) Potential Downsides

While Reishi is generally considered safe for most people, there are some potential downsides:

• May interact with certain medications, particularly those affecting the immune system and blood clotting
• Potential liver toxicity with long-term use or high doses
• Common side effects can include digestive issues, skin rash, and dizziness

Caution is advised for pregnant or breastfeeding women, as there is insufficient evidence to determine safety.

5) Genetic Variations and Reishi

Currently, there is limited research on the interaction between genetic variations and the effects of Reishi mushrooms. Some preliminary studies suggest that individuals with certain genetic profiles may experience more pronounced immune system benefits or risks. However, more research is needed in this area to make definitive claims.

Always consult with a healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or are taking other medications.

Reishi Mushroom (Ganoderma lucidum) Research Summary

Antioxidant Properties

Studies have indicated that Ganoderma lucidum (Reishi mushroom) exhibits strong antioxidant activity, effective in preventing lipid peroxidation, scavenging free radicals, and chelating ferrous ions. The antioxidant properties are attributed to the high total phenol content in the mushroom's extracts.

Cultivation and Bioactive Components

Reishi mushroom is cultivated artificially due to its rarity in the wild. The primary bioactive components are triterpenoids and polysaccharides, which offer health benefits such as liver protection, blood pressure reduction, cholesterol-lowering, anti-tumor effects, and immune system modulation.

Medicinal and Cultural Significance

Reishi mushroom has been valued in Chinese culture for its therapeutic properties and is used in various forms like powders, supplements, and tea. Scientific studies support some of the health claims associated with Reishi, including managing blood sugar levels and boosting the immune system.

Pharmacological Properties

The compounds in mushrooms like Reishi have shown a range of pharmacological properties including antimicrobial, antiviral, antitumor, antiallergic, and immunomodulatory activities, which are based on recent scientific literature.

Immunomodulatory Effects

Reishi mushrooms have been researched for their effects on human immune cells, with findings indicating modulation of gene expression and immune system responses. Different species of Ganoderma may have distinct biological effects on cellular pathways.

Cholesterol and Fatty Acids

Comparative studies between Ganoderma lucidum and Ganoderma sinense show differences in the content of sterols and fatty acids, which may contribute to their antitumor effects.

Polysaccharide Analysis

Research comparing polysaccharides from two species of Ganoderma reveals similarities in profiles and molecular weights, suggesting similar polysaccharide structures despite differences in other components.

Ganoderic Acids and Quality Analysis

Studies on Ganoderma lucidum varieties show significant differences in ganoderic acids and polysaccharides content, influencing quality. Advanced HPLC methods are effective for evaluating and analyzing triterpene content in Reishi products.

Immune-modulating and Tumor-inhibitory Effects

Reishi mushrooms have been recognized for their potential immune-modulating and tumor-inhibitory effects, but more detailed studies are needed to understand their mechanisms and broader biological impacts.

Novel Polysaccharides and Structural Characterization

Isolation and characterization of novel beta-D-glucan polysaccharides from Reishi spores show immunomodulatory properties and suggest their use in conjunction with cancer treatments.

Antiviral and Antiherpetic Properties

Studies on the proteoglycan GLPG from Reishi mycelia indicate antiviral activity against herpes simplex virus and potential as an antiviral agent.

Anticancer and Immune System Activation

Research on Reishi immunomodulating substances (GLIS) suggests activation of the immune system by altering cytokine production, which may have anti-cancer properties.

Antioxidant Properties of Glycopeptides

Investigation into the antioxidant properties of glycopeptides from Reishi fruiting bodies reveals potential as a source of natural antioxidants.

Mushroom Selenium Content

Studies on the selenium content in mushrooms highlight the importance of selenium for human health and the high levels found in certain wild and selenium-enriched mushroom species.

Nutritional and Genotoxic Effects

Research on Ganoderma extract shows modest nutritional value and no genotoxic effects in mice, supporting claims that it protects against mutagens.

Hepatotoxicity Concerns

Despite reported health benefits, there have been cases of severe liver damage associated with the consumption of powdered Reishi mushroom, indicating the need for caution and further safety monitoring.

References:

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2. Ganoderma lucidum and its pharmaceutically active compounds
3. Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom
4. The pharmacological potential of mushrooms
5. The effects of two different ganoderma species (Lingzhi) on gene expression in human monocytic THP-1 cells
6. Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum
7. Comparison of sterols and fatty acids in two species of Ganoderma
8. Comparison of polysaccharides from two species of Ganoderma
9. Quality Difference Study of Six Varieties of Ganoderma lucidum with Different Origins
10. Quantitative determination of bitter principles in specimens of Ganoderma lucidum using high-performance liquid chromatography and its application to the evaluation of ganoderma products
11. Mushrooms, tumors, and immunity
12. Structure and Conformation Behavior of a Glucan from Spores of Ganoderma lucidum (Fr.) Karst
13. Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst
14. Chemical modifications of the (1-->3)-alpha-D-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity
15. Structural features of immunologically active polysaccharides from Ganoderma lucidum
16. NMR characterization for polysaccharide moiety of a glycopeptide
17. Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast
18. Possible mechanism underlying the antiherpetic activity of a proteoglycan isolated from the mycelia of Ganoderma lucidum in vitro
19. Immunomodulation of RAW264.7 macrophages by GLIS, a proteopolysaccharide from Ganoderma lucidum
20. A new class of natural glycopeptides with sugar moiety-dependent antioxidant activities derived from Ganoderma lucidum fruiting bodies
21. Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord blood
22. Purification, characterization, and modification of T lymphocyte-stimulating polysaccharide from spores of Ganoderma lucidum
23. A novel water-soluble β-D-glucan isolated from the spores of Ganoderma lucidum
24. HPLC determination of four triterpenoids in rat urine after oral administration of total triterpenoids from Ganoderma lucidum
25. Structure-activity relationships of ganoderma acids from Ganoderma lucidum as aldose reductase inhibitors
26. The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain
27. Qualitative and quantitative analyses of nucleosides and nucleobases in Ganoderma spp. by HPLC-DAD-MS
28. Ling Zhi-8: studies of a new immunomodulating agent
29. Ganodermin, an antifungal protein from fruiting bodies of the medicinal mushroom Ganoderma lucidum
30. Purification and characterization of lectin from fruiting body of Ganoderma lucidum: lectin from Ganoderma lucidum
31. Isolation and characterization of alpha-glucosidase inhibitor from the fungus Ganoderma lucidum
32. New lanostanoids from the mushroom Ganoderma lucidum
33. [Determination of ergosterol in Ganoderma lucidum from different varieties and cultured tree species by HPLC]
34. Isolation and identification of C-19 fatty acids with anti-tumor activity from the spores of Ganoderma lucidum (reishi mushroom)
35. Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity
36. Copper and zinc bioaccumulation and bioavailability of Ganoderma lucidum
37. Selenium in edible mushrooms
38. Nutritional value of ganoderma extract and assessment of its genotoxicity and antigenotoxicity using comet assays of mouse lymphocytes
39. Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum
40. A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia
41. Immuno-potentiating effects of the antler-shaped fruiting body of Ganoderma lucidum (Rokkaku-Reishi)
42. Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK
43. Anti-tumor activities of the antlered form of Ganoderma lucidum in allogeneic and syngeneic tumor-bearing mice
44. Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease
45. A new ganoderic acid from Ganoderma lucidum mycelia
46. The water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia (Designated as MAK) ameliorates murine colitis induced by trinitrobenzene sulphonic acid
47. In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury
48. Ganoderma lucidum mycelium and spore extracts as natural adjuvants for immunotherapy
49. Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways
50. Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways
51. Immune receptors for polysaccharides from Ganoderma lucidum
52. Oligosaccharide and peptidoglycan of Ganoderma lucidum activate the immune response in human mononuclear cells
53. Macrophage immunomodulatory activity of a purified polysaccharide isolated from Ganoderma atrum
54. Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum
55. Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling
56. GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor α-induced expression of matrix metalloproteinase 9 via NF-κB pathway in human alveolar epithelial A549 cells
57. Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides
58. Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice
59. Effect of mycelial culture broth of Ganoderma lucidum on the growth characteristics of human cell lines
60. Effect of Ganoderma lucidum on cytokine release by peritoneal macrophages
61. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial
62. Tumor necrosis factor-alpha induces MMP-9 expression via p42/p44 MAPK, JNK, and nuclear factor-kappaB in A549 cells
63. p53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells
64. Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1
65. Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling
66. The differential immunological activities of Ganoderma lucidum on human pre-cancerous uroepithelial cells
67. Development of a new method for improved identification and relative quantification of unknown metabolites in complex samples: determination of a triterpenoid metabolic fingerprint for the in situ characterization of Ganoderma bioactive compounds
68. HPLC method for the determination and pharmacokinetic studies of four triterpenoids in rat plasma after oral administration of Ganoderma lucidum extract
69. Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum
70. Triterpenoids with neurotrophic activity from Ganoderma lucidum
71. Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells
72. Ganoderma lucidum reduces kainic acid-induced hippocampal neuronal damage via inflammatory cytokines and glial fibrillary acid protein expression
73. [Ganoderma lucidum extract protects dopaminergic neurons through inhibiting the production of inflammatory mediators by activated microglia]
74. Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation
75. Neurasthenia: prevalence, disability and health care characteristics in the Australian community
76. Depression in the planet's largest ethnic group: the Chinese
77. Extract of Ganoderma lucidum prolongs sleep time in rats
78. Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism
79. [Sleep-promoting effects of Ganoderma extracts in rats: comparison between long-term and acute administrations]
80. Potentiation of ganodermic acid S on prostaglandin E(1)-induced cyclic AMP elevation in human platelets
81. Differential effects of ganodermic acid S on the thromboxane A2-signaling pathways in human platelets
82. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers
83. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice
84. Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs
85. Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors
86. Ganoderic acid and its derivatives as cholesterol synthesis inhibitors
87. Isolation and structure determination of a cholesterol esterase inhibitor from Ganoderma lucidum
88. Metabolic fate of pancreas-derived cholesterol esterase in intestine: an in vitro study using Caco-2 cells
89. Lipid-lowering effects of WAY-121,898, an inhibitor of pancreatic cholesteryl ester hydrolase
90. Ganoderma lucidum polysaccharides exert anti-hyperglycemic effect on streptozotocin-induced diabetic rats through affecting β-cells
91. Hypoglycemic effect and mechanism of a proteoglycan from ganoderma lucidum on streptozotocin-induced type 2 diabetic rats
92. Antihyperglycemic effect of ganoderma lucidum polysaccharides on streptozotocin-induced diabetic mice
93. Reishi Protein LZ-8 Induces FOXP3(+) Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice
94. Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells
95. Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine macrophages and T lymphocytes
96. Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis
97. Metastasis: quantitative analysis of distribution and fate of tumor emboli labeled with 125 I-5-iodo-2'-deoxyuridine
98. Role of NK cells in the control of metastatic spread and growth of tumor cells in mice
99. The role of natural killer cells in the control of tumor growth and metastasis
100. Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer
101. Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients
102. Extraction of polysaccharide from Ganoderma lucidum and its immune enhancement activity
103. Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo
104. Inhibition by fibrin coagulation of lung cancer cell destruction by human interleukin-2-activated killer cells
105. Ganoderma lucidum polysaccharides eradicates the blocking effect of fibrinogen on NK cytotoxicity against melanoma cells
106. Enhanced MHC class I and costimulatory molecules on B16F10 cells by Ganoderma lucidum polysaccharides
107. [Activation of mouse macrophages by the alkali-extracted polysaccharide from spore of Ganoderma lucidum]
108. Immunomodulation of bone marrow macrophages by GLIS, a proteoglycan fraction from Lingzhi or Reishi medicinal mushroom Ganoderma lucidium (W.Curt.:Fr.) P. Karst
109. [Study on antitumor activity and mechanism of Ganoderma polysaccharides B]
110. Submerged cultivation of Ganoderma lucidum biomass and immunostimulatory effects of fungal polysaccharides
111. Medicinal mushroom Lingzhi or Reishi, Ganoderma lucidum (W.Curt.:Fr.) P. Karst., beta-glucan induces Toll-like receptors and fails to induce inflammatory cytokines in NF-kappaB inhibitor-treated macrophages
112. Protective effects of Ganoderma lucidum polysaccharides peptide on injury of macrophages induced by reactive oxygen species
113. Preferential induction of Th17 cells in vitro and in vivo by Fucogalactan from Ganoderma lucidum (Reishi)
114. Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides
115. Regulatory effect of Ganoderma lucidum polysaccharides on cytotoxic T-lymphocytes induced by dendritic cells in vitro
116. An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and MAPK pathways
117. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
118. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
119. "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance
120. Immune changes induced by exercise in an adverse environment
121. Effect of Ganoderma lucidum capsules on T lymphocyte subsets in football players on "living high-training low"
122. Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities
123. Activation of B lymphocytes by GLIS, a bioactive proteoglycan from Ganoderma lucidum
124. Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor Blimp-1
125. Control of B-cell responses by Toll-like receptors
126. Effect of medicinal plant extracts on forced swimming capacity in mice
127. Anti-androgenic activities of Ganoderma lucidum
128. Anti-androgen effects of extracts and compounds from Ganoderma lucidum
129. The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum
130. Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor
131. Ganoderma lucidum is an inhibitor of testosterone-induced prostatic hyperplasia in rats
132. Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms
133. Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling
134. Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum
135. The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum
136. Isolation and hypoglycemic activity of ganoderans A and B, glycans of Ganoderma lucidum fruit bodies
137. Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies
138. Hypoglycemic effect of Ganoderma lucidum polysaccharides
139. HPLC analysis of Ganoderma lucidum polysaccharides and its effect on antioxidant enzymes activity and Bax, Bcl-2 expression
140. In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damage
141. A protein tyrosine phosphatase 1B activity inhibitor from the fruiting bodies of Ganoderma lucidum (Fr.) Karst and its hypoglycemic potency on streptozotocin-induced type 2 diabetic mice
142. Effect of a novel proteoglycan PTP1B inhibitor from Ganoderma lucidum on the amelioration of hyperglycaemia and dyslipidaemia in db/db mice
143. ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK
144. [Effect of Ganoderma lucidum polysaccharides on hemodynamic and antioxidation in T2DM rats]
145. Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum
146. Farnesoid X receptor: from structure to potential clinical applications
147. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial
148. Ganoderma lucidum polysaccharide accelerates refractory wound healing by inhibition of mitochondrial oxidative stress in type 1 diabetes
149. Effect of polysaccharides from Ganoderma lucidum on streptozotocin-induced diabetic nephropathy in mice
150. An immunomodulating protein, Ling Zhi-8 (LZ-8) prevents insulitis in non-obese diabetic mice
151. Protective effects of Ganoderma lucidum spore on cadmium hepatotoxicity in mice
152. Hepatoprotective effects of Ganoderma lucidum peptides against D-galactosamine-induced liver injury in mice
153. Ganoderma lucidum protects liver mitochondrial oxidative stress and improves the activity of electron transport chain in carbon tetrachloride intoxicated rats
154. Antimutagenic activity of methanolic extract of Ganoderma lucidum and its effect on hepatic damage caused by benzo[a]pyrene
155. Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice
156. Effects of Ganoderma lucidum on obstructive jaundice-induced oxidative stress
157. Post-treatment of Ganoderma lucidum reduced liver fibrosis induced by thioacetamide in mice
158. Inhibitory effects of ganoderma lucidum on tumorigenesis and metastasis of human hepatoma cells in cells and animal models
159. Evaluation of antiproliferative activities and action mechanisms of extracts from two species of Ganoderma on tumor cell lines
160. Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum
161. Anti-hepatitis activities in the broth of Ganoderma lucidum supplemented with a Chinese herbal medicine
162. Ginseng and Ganoderma lucidum use after breast cancer diagnosis and quality of life: a report from the Shanghai Breast Cancer Survival Study
163. Cytotoxic activity of methanol extracts from Basidiomycete mushrooms on murine cancer cell lines
164. Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells by the Ganoderma lucidum and Duchesnea chrysantha extracts
165. Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells
166. Preparation, characterization, and antiproliferative activities of the Se-containing polysaccharide SeGLP-2B-1 from Se-enriched Ganoderma lucidum
167. Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells
168. Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells
169. Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell
170. [Effect of Ganoderma lucidum polysaccharides peptide on invasion of human lung carcinoma cells in vitro]
171. Effect of Ganoderma on drug-sensitive and multidrug-resistant small-cell lung carcinoma cells
172. Antitumor activity of the sporoderm-broken germinating spores of Ganoderma lucidum
173. New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells
174. Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest
175. Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3
176. The effect of a novel botanical agent TBS-101 on invasive prostate cancer in animal models
177. Ganoderma lucidum extracts inhibit growth and induce actin polymerization in bladder cancer cells in vitro
178. The dual roles of Ganoderma antioxidants on urothelial cell DNA under carcinogenic attack
179. Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells
180. Ganoderma lucidum extract inhibits proliferation of SW 480 human colorectal cancer cells
181. Studies on fungal polysaccharides. XXVII. Structural examination of a water-soluble, antitumor polysaccharide of Ganoderma lucidum
182. Update from Asia. Asian studies on cancer chemoprevention
183. Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance
184. Prevention of the development of preneoplastic lesions, aberrant crypt foci, by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male F344 rats
185. A water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia suppresses azoxymethane-induction of colon cancers in male F344 rats
186. Effect of Reishi polysaccharides on human stem/progenitor cells
187. Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide
188. Isoflavone aglycon produced by culture of soybean extracts with basidiomycetes and its anti-angiogenic activity
189. A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas
190. Effects on tyrosinase activity by the extracts of Ganoderma lucidum and related mushrooms
191. Hepatotoxicity due to a formulation of Ganoderma lucidum (lingzhi)
192. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder
193. Regression of prostate cancer following administration of Genistein Combined Polysaccharide (GCP), a nutritional supplement: a case report
194. Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer
195. Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study
196. Antimicrobial activity of Ganoderma lucidum extract alone and in combination with some antibiotics

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