Rose Hip Overview

1. Conditions Studied

Rose hip has been studied for various conditions, including:

• Osteoarthritis
• Rheumatoid arthritis
• Lower back pain
• Inflammation
• Gastrointestinal disorders
• Obesity
• Cardiovascular diseases
• Diabetes
• Common cold and immune system support

2. Effectiveness in Treating Conditions

Research findings on rose hip's effectiveness are mixed:

• Some studies suggest that rose hip powder can reduce pain and improve mobility in people with osteoarthritis.
• It may have anti-inflammatory effects which could help with rheumatoid arthritis and other inflammatory conditions.
• There is limited evidence for its effectiveness in treating lower back pain and gastrointestinal disorders.
• Its role in weight management, cardiovascular health, and diabetes needs further investigation.
• Rose hip may help reduce the duration and severity of colds by supporting the immune system.

3. Health Benefits

Rose hip is known for its potential health benefits, such as:

• Being rich in vitamin C, antioxidants, and polyphenols.
• Helping to protect against chronic diseases due to its antioxidant properties.
• Contributing to skin health and possibly reducing skin aging, thanks to its vitamin A content and antioxidant action.
• Supporting immune function.
• Possibly aiding in weight loss and fat metabolism.

4. Downsides

While rose hip is generally considered safe, there are some potential downsides:

• May cause allergic reactions in some individuals.
• High doses can lead to stomach upset, heartburn, diarrhea, and constipation.
• Excessive consumption of rose hip can lead to kidney stones due to its vitamin C content.
• May interact with certain medications, such as blood thinners and anti-inflammatory drugs.
• Pregnant and breastfeeding women should consult a healthcare provider before consuming rose hip supplements.

5. Impact on Genetic Variations

There is limited research on the relationship between rose hip consumption and specific genetic variations. However:

• Individuals with certain genetic predispositions to kidney stones might need to be cautious due to its vitamin C content.
• Genetic variations affecting metabolism could potentially influence how an individual responds to the active compounds in rose hip.
• Further research is warranted to provide clear guidance on the interaction between rose hip and genetic variations.

Research Summary on Rose Hip (Rosa canina L.)

Pharmacological Effects and Clinical Studies

Rose hip preparations exhibit antioxidative and anti-inflammatory properties, primarily due to their lipophilic constituents. The rose hip and seed powder known as Litozin has been studied for potential benefits in treating osteoarthritis, rheumatoid arthritis, and low back pain. Its clinical effects, along with contributions to weight loss as part of a low-calorie diet, require further investigation.

Antioxidant Properties

Vitamin C, total polyphenols, and total flavonoids in Rosa canina L. biotypes from Transylvania show significant variation. Two genotypes, in particular, demonstrate high levels of phytochemicals and antioxidant activity, indicating their potential as natural antioxidants.

Anti-Inflammatory Components

A specific galactolipid compound found in rose hip inhibits the movement of human neutrophils without toxicity, suggesting a possible mechanism for rose hip's traditional use as an anti-inflammatory remedy.

Proanthocyanidin Composition

Studies using HPLC-ESI-MS have identified a variety of proanthocyanidin aglycones and glycosides in dog rose hips. A method for estimating the total concentration of these compounds has been developed, confirming the presence of high levels of Vitamin C.

Obesity and Metabolic Effects

Rosehip extract and tiliroside have been shown to reduce fat accumulation in cell culture and mouse models. They affect the expression of transcription factors in fat cells and contribute to reduced body weight and visceral fat in mice on high-fat diets.

Immunomodulatory Effects

Triterpene acids extracted from standardized rose hip powder exhibit immunomodulatory properties, reducing the release of pro-inflammatory cytokines and suppressing the proliferation of immune cells. The concentration required for these effects in clinical settings is still under consideration.

Method for Measuring Vitamin C in Rose Hips

A quick and selective RP-HPLC method has been developed to measure L-ascorbic acid in rose hips, providing a reliable way to assess ascorbic acid content in commercial products and fresh rose hips.

Kidney Stone Prevention

Rosa canina fruit extract has demonstrated effectiveness in preventing calcium oxalate kidney stones in rats, reducing kidney damage and stone formation.

Carotenoid Content and Pharmacological Activities

Different extraction methods have identified primary carotenoids in rose hips, showing varied pharmacological effects including anti-Helicobacter pylori activity, cytotoxic effects, MDR reversal, and free radical scavenging.

Mineral and Trace Element Content in Medicinal Herbs

The study analyzed the content of minerals and trace elements in various medicinal herbs, including rosehip, using FAAS and ICP-AES. The distribution of elements in infusions was generally low, with some elements at negligible levels.

Anti-Inflammatory and Antidiabetic Properties

Rose hip powder has been studied for its effects on osteoarthritis pain reduction, metabolic risk markers, and body fat reduction. It has shown potential as a natural supplement for preventing obesity and improving cardiovascular risk factors in obese individuals.

Conclusion

Rose hip shows promising pharmacological effects as an antioxidative and anti-inflammatory agent, with potential applications in treating various conditions. However, further research is needed to confirm its clinical efficacy and determine optimal preparations for medicinal use.

References:

1. A systematic review on the Rosa canina effect and efficacy profiles
2. Bioactive compounds and antioxidant activity of Rosa canina L. biotypes from spontaneous flora of Transylvania
3. An antiinflammatory galactolipid from rose hip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro
4. Characterisation of proanthocyanidin aglycones and glycosides from rose hips by high-performance liquid chromatography-mass spectrometry, and their rapid quantification together with vitamin C
5. Rosehip Extract Inhibits Lipid Accumulation in White Adipose Tissue by Suppressing the Expression of Peroxisome Proliferator-activated Receptor Gamma
6. Potent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside
7. Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)
8. Triterpene acids from rose hip powder inhibit self-antigen- and LPS-induced cytokine production and CD4⁺ T-cell proliferation in human mononuclear cell cultures
9. Fast and Selective Assay of l-Ascorbic Acid in Rose Hips by RP-HPLC Coupled with Electrochemical and/or Spectrophotometric Detection
10. The effects of the hydroalcohol extract of Rosa canina L. fruit on experimentally nephrolithiasic Wistar rats
11. Carotenoid composition and in vitro pharmacological activity of rose hips
12. Determination of mineral and trace elements in some medicinal herbs and their infusions consumed in Turkey
13. The role of flavonoids in false positive digoxin assays caused by the consumption of hibiscus flower and rose hip tea
14. Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons
15. Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice
16. Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program
17. Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial
18. The role of cytokines in cartilage matrix degeneration in osteoarthritis
19. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis
20. Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments
21. Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression
22. Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis
23. Differential effects of IL-8, LIF (pro-inflammatory) and IL-11 (anti-inflammatory) on TNF-alpha-induced PGE(2)release and on signalling pathways in human OA synovial fibroblasts
24. Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes
25. The anti-inflammatory properties of rose-hip
26. Improved gait in persons with knee related mobility limitations by a rosehip food supplement: A randomized, double-blind, placebo-controlled trial
27. Rose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivo
28. The effects of rose hip (Rosa canina) on plasma antioxidative activity and C-reactive protein in patients with rheumatoid arthritis and normal controls: a prospective cohort study
29. Rose hip herbal remedy in patients with rheumatoid arthritis - a randomised controlled trial
30. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee
31. A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial
32. A herbal remedy, Hyben Vital (stand. powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis--a double-blind, placebo-controlled, randomised trial
33. The migratory and phagocytic activity of polymorphonuclear leukocytes in rheumatoid arthritis and osteoarthritis patients
34. Negative regulation of adipogenesis by kaempferol, a component of Rhizoma Polygonati falcatum in 3T3-L1 cells
35. AMP-activated protein kinase in skeletal muscle: from structure and localization to its role as a master regulator of cellular metabolism
36. The effects of AICAR on adipocyte differentiation of 3T3-L1 cells
37. The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity
38. Cosmetic benefits of astaxanthin on humans subjects
39. Lady Prelox® improves sexual function in generally healthy women of reproductive age
40. Lady Prelox® improves sexual function in post-menopausal women
41. Lady Prelox® improves sexual function in post-menopausal women
42. Supplementation with Pycnogenol® improves signs and symptoms of menopausal transition

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