Royal Jelly - NutraPedia

Back to Table of Contents

Royal Jelly Overview

1) Conditions Studied for Royal Jelly

Royal jelly has been studied for a variety of conditions, including but not limited to:

Menopausal symptoms
High cholesterol
Diabetes
Infertility issues
Wound healing and skin disorders
Immune system enhancement

2) Efficacy in Treating Conditions

The effectiveness of royal jelly in treating these conditions is still under scientific investigation, with mixed results:

Some studies suggest benefits in menopausal symptoms and wound healing.
There is limited evidence on its positive effects on cholesterol and diabetes.
Research on fertility and immune system improvement is inconclusive.

More rigorous and extensive clinical trials are needed to substantiate these claims.

3) Health Benefits of Royal Jelly

Royal jelly may offer several health benefits, such as:

Antioxidant properties
Anti-inflammatory effects
Potential to improve cognitive function
May support skin health

However, it's important to note that the evidence for these benefits varies in quality and is not universally accepted.

4) Downsides of Royal Jelly

While many people can safely consume royal jelly, there are potential downsides:

Allergic reactions, particularly in individuals who are allergic to bees or bee products
Possible interactions with certain medications
Quality and potency can vary between products

It is recommended to consult with a healthcare provider before beginning any new supplement regimen, including royal jelly.

5) Royal Jelly and Genetic Variations

Research on the relationship between royal jelly and specific genetic variations is limited. However, here are a few considerations:

Individuals with certain genetic predispositions to allergies may have an increased risk of adverse reactions to royal jelly.
There is ongoing research into how genetic variations may affect the metabolism and effectiveness of various supplements, including royal jelly.

Until more definitive research is available, it is difficult to make concrete statements about the benefits or harms of royal jelly for specific genetic variations.

Royal Jelly Research Summary

Development of UPLC Method for RJ Freshness: A study developed a rapid ultraperformance liquid chromatography (UPLC) method to assess the freshness and quality of royal jelly (RJ) by measuring ATP and its breakdown products. The recovery rates were between 86.0% and 102.3% with high precision and the method was successfully applied to RJ samples.

10-Hydroxy-trans-2-decenoic Acid in RJ: Research found that 10-Hydroxy-trans-2-decenoic acid (10H2DA), a major RJ component, inhibits the production of nitric oxide and tumor necrosis factor-alpha, potentially modulating immune responses.

Choline Esters in RJ: A study focused on confirming the presence of acetylcholine, a known neurotransmitter, in royal jelly, suggesting significant biological functions for RJ components.

Protective Effects of RJ on Chemotherapy Damage: RJ showed protective effects against oxidative stress and apoptosis in the liver and kidneys of rats caused by the chemotherapy drug cisplatin.

RJ in Preventing and Treating Periodontal Diseases: RJ was found to have bone-inducing (osteoinductive) and anti-inflammatory effects, beneficial for managing periodontal diseases.

Anti-Aging Effects of RJ on Skin: Research indicated that RJ may protect against skin aging by promoting collagen production, particularly in rats with estrogen deficiency.

Queen Differentiation Induced by Royalactin: Royalactin, a protein in RJ, was shown to induce larval development into queens in honeybees and had similar effects on fruit flies, suggesting its action via the Egfr signaling pathway.

RJ and Traditional Medicines for Mibyou: RJ's weak estrogenic activity was studied, revealing its ability to bind to human estrogen receptors and promote cell proliferation, which may offer pharmacological functions.

RJ Protects against Paracetamol-Induced Liver Damage: A study concluded that royal jelly could significantly protect the liver from damage induced by paracetamol.

Negative Impacts of RJ on Pubertal Male Rats: High doses of RJ adversely affected the reproductive system of young male rats, with potential partial recovery after discontinuation.

Insulin-like and Immunological Activities in RJ: Research investigated RJ's hypoglycemic effects and immunological properties, contributing to its use in alternative medicine.

Immunomodulatory Effects of RJ Fatty Acids: Fatty acids in RJ, such as 10-HDA and 3,10-DDA, were found to have immunomodulatory effects, influencing T-cell and dendritic cell cultures.

RJ and Bee Pollen on Osteoporosis: RJ and bee pollen decreased bone loss in an oophorectomized rat model, suggesting implications for treating osteoporosis.

AMP N1-oxide in RJ and Nerve Growth: AMP N1-oxide, identified in RJ, was significantly more potent than AMP in inducing nerve growth-promoting activity in rat pheochromocytoma PC12 cells.

Allergic Reactions to RJ: An individual with asthma experienced a severe reaction after consuming RJ, emphasizing potential risks for those with respiratory conditions.

Estrogen-like Effects of RJ Fatty Acids: RJ-derived fatty acids impacted estrogen receptor functions, suggesting a novel mechanism of estrogenic activity.

IgE-mediated Hypersensitivity to RJ: A study confirmed that asthma and anaphylaxis symptoms after RJ ingestion were true IgE-mediated hypersensitivity reactions.

Long-term RJ Consumption Benefits: A six-month study showed that RJ consumption led to better red blood cell production, glucose tolerance, and mental health in humans.

RJ on Autoimmune Responses in Graves' Disease: RJ acted as an immunomodulatory agent in Graves' disease treatment, potentially offering an alternative to conventional drugs.

RJ Effect on Lipoprotein Metabolism: RJ supplementation significantly reduced serum total cholesterol and LDL, suggesting improvements in cholesterol profiles.

Mimicking Estrogen with RJ: RJ weakly bound to human estrogen receptors, influencing gene transcription and potentially relieving menopausal symptoms.

Melbrosia for Menopausal Symptoms: Melbrosia, containing bee products, was found to reduce menopausal symptoms and improve cardiovascular markers in postmenopausal women.

Lifespan-Extending Effects of RJ: RJ and protease-treated RJ increased the lifespan of C. elegans by activating longevity-associated pathways, suggesting its potential in promoting longevity.

References:

Upload Whole Genome Sequencing (WGS) raw DNA data today and take a deep dive into your genome!

Or if you only have standard microarray data currently, upload raw DNA data to get started with your free DNA raw data analysis today!