Effects of Schisandra and Its Compounds on Health

Anti-inflammatory Properties

Studies have shown that gomisins A, G, and J from Schisandria chinensis have anti-inflammatory effects on macrophages, inhibiting production of pro-inflammatory cytokines and the NF-κB pathway, particularly through HO-1 signaling.

Cardioprotective Responses

Schisandra chinensis compounds, especially schisandrin B (Sch B) and schisandrin C (Sch C), can trigger cardioprotective responses through reactive oxidant species (ROS) production, inducing a glutathione antioxidant response.

Reversing Multidrug Resistance

Schisandrol A (SCH) from Schisandra chinensis has been found to reverse multidrug resistance in cancer cells by interfering with P-glycoprotein and drug complexes, suggesting a potential mechanism for enhancing chemotherapy effectiveness.

Immunostimulatory Effects

A water-soluble polysaccharide, SCP-IIa, from Schisandra chinensis has shown potential as an immunostimulant, enhancing thymus and spleen size, and increasing the activity of peritoneal macrophages.

Nortriterpenoid Compounds

New nortriterpenoid compounds, wuweizidilactones A-F, have been discovered in Schisandra chinensis, contributing to the understanding of the plant's chemical diversity and potential biological activities.

Liver Health

Traditional Chinese medicine formulations containing Schisandra chinensis, such as Shengmai San (SMS), have been shown to reduce liver cholesterol and triglyceride levels and enhance antioxidant systems in cholesterol-fed rats.

Neuroprotective and Anticancer Potential

Compounds like deoxyschisandrin and α-iso-cubebenol from Schisandra chinensis have demonstrated neuroprotective properties and anticancer potential by inducing apoptosis in liver cancer cells independent of the p53 pathway.

Sedative and Hypnotic Effects

The ethanol extract of Schisandra chinensis fruit has been found to have sedative and hypnotic properties, suggesting its traditional use for treating insomnia may have scientific support.

Conclusion

Schisandra chinensis and its compounds exhibit a range of beneficial effects including anti-inflammatory, cardioprotective, immune-boosting, anticancer, neuroprotective, and sedative properties, making it a valuable subject for further therapeutic research.

References:

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