Toothache Plant - NutraPedia

Back to Table of Contents

Toothache Plant (Acmella oleracea) Overview

1) Conditions Studied for Treatment

The toothache plant has been traditionally used and studied for various conditions, including but not limited to:

Toothache and oral discomfort
Throat and mouth infections
Anti-inflammatory conditions
Analgesic purposes
Gastrointestinal issues like dysentery and stomachaches

2) Efficacy in Treating Conditions

Research suggests that the toothache plant may have some effectiveness in treating these conditions due to its analgesic and anti-inflammatory properties. However, more comprehensive clinical trials are needed to establish its efficacy conclusively. Traditional use and anecdotal evidence support its role in oral health and pain relief.

3) Health Benefits

The toothache plant is believed to offer several health benefits, including:

Pain relief, particularly in dental pain
Anti-inflammatory effects which can help reduce swelling and redness
Antimicrobial properties that may protect against bacterial infections
Potential to alleviate sore throat and cough when used as a gargle

4) Potential Downsides

While the toothache plant is generally considered safe when used in moderation, there are some potential downsides to be aware of:

Overuse might lead to irritation or allergic reactions in some individuals
Lack of extensive scientific studies to fully understand the long-term effects
Possible interactions with other medications or underlying health conditions

5) Genetic Variations and Effects

Currently, there is limited research on the interaction between genetic variations and the effects of the toothache plant. Personal genetic differences can influence how individuals respond to herbal remedies, but specific links to the toothache plant have not been well-studied. It is advisable to consult with a healthcare professional before using the plant, especially for those with known genetic conditions affecting drug metabolism.

Research Summary: Toothache Plant (Spilanthes acmella)

Introduction

The Toothache Plant, Spilanthes acmella, is a medicinal herb recognized for its therapeutic properties including antimicrobial, antioxidant, and anti-inflammatory effects. It is traditionally used to treat toothache, rheumatism, and fever.

Isolation and Biological Activity of Compounds

Research isolated bioactive compounds from S. acmella flower buds, including spilanthol and two N-isobutylamides, effective against Aedes aegyptii mosquito larvae and Helicoverpa zea moth neonates. The chemical structures were determined through spectroscopic methods.

Transdermal Absorption of Spilanthol

Studies show that spilanthol, an N-alkylamide found in S. acmella, can penetrate the skin. This supports its potential for topical application and contributes to our understanding of local pharmacokinetics of N-alkylamides.

Anti-Obesity Potential

Extracts from S. acmella showed the ability to inhibit pancreatic lipase, suggesting potential for weight loss management.

Sexual Enhancement Properties

S. acmella flower extract improved sexual behavior in male rats and influenced hormone levels, supporting its use as an aphrodisiac.

Antimicrobial and Antioxidant Activities

Extracts from S. acmella demonstrated antimicrobial and antioxidant activities, with certain fractions inhibiting the growth of various microbes and showcasing radical scavenging ability without cytotoxic effects.

Diuretic Effect

A cold-water extract of S. acmella flowers significantly increased urine output in rats, supporting its traditional use as a diuretic.

Anti-Inflammatory Mechanism

Spilanthol from S. acmella reduced inflammatory responses by down-regulating key inflammatory mediators through the inhibition of the NF-kappaB pathway.

Local Anesthetic and Antipyretic Activities

An aqueous extract of S. acmella exhibited local anesthetic and antipyretic activities in animal models, affirming its traditional medicinal applications.

Conclusion

The extensive research on Spilanthes acmella confirms its range of medicinal properties and provides a scientific basis for its traditional uses, particularly as a treatment for toothache. The plant's bioactive compounds, notably spilanthol, contribute to its effectiveness in various applications, from pest control to enhancing sexual health.

References:

Upload Whole Genome Sequencing (WGS) raw DNA data today and take a deep dive into your genome!

Or if you only have standard microarray data currently, upload raw DNA data to get started with your free DNA raw data analysis today!