Vitamin A - NutraPedia

Back to Table of Contents

Vitamin A Overview

1) Conditions Studied

Vitamin A has been studied for a variety of conditions, including:

  • Measles
  • Age-related macular degeneration
  • Acute promyelocytic leukemia
  • HIV/AIDS
  • Skin conditions such as acne
  • Immune system deficiencies

2) Effectiveness in Treating Conditions

The effectiveness of Vitamin A in treating these conditions varies:

  • Supplementation can be beneficial in preventing complications associated with measles in children.
  • It has shown some promise in slowing the progression of age-related macular degeneration when taken in combination with other antioxidants.
  • High doses of Vitamin A derivatives are used effectively to treat acute promyelocytic leukemia.
  • The role of Vitamin A in HIV/AIDS is still under research, with some studies suggesting benefits in reducing mother-to-child transmission.
  • Topical and oral forms of Vitamin A derivatives can be effective for acne treatment.

3) Health Benefits

  • Essential for healthy vision
  • Supports the immune system
  • Important for cell growth and differentiation
  • Plays a role in bone health
  • Antioxidant properties

4) Downsides

  • Excessive intake can lead to toxicity, known as hypervitaminosis A
  • High doses during pregnancy can cause birth defects
  • Can interact with certain medications, such as blood thinners and retinoids

5) Genetic Variations and Impacts

While there is ongoing research into the relationship between genetic variations and Vitamin A metabolism, some studies suggest:

  • Individuals with certain genetic variations may be more susceptible to Vitamin A deficiency or toxicity.
  • Some genetic disorders, such as abetalipoproteinemia, affect the body's ability to absorb and use Vitamin A.
  • Genetic testing can sometimes help identify individuals who might require personalized dietary guidelines for Vitamin A.

Vitamin A: Dietary Reference Intakes

The National Academy of Sciences has released a new volume in its series on dietary reference intakes (DRIs). This volume focuses on the recommended intakes for Vitamin A and other nutrients. The guidelines suggest appropriate intake levels to support healthy diets for various age groups and genders, as well as to prevent chronic diseases. Moreover, a new reference point, the Tolerable Upper Intake Level (UL), is introduced to caution against the excessive consumption of these nutrients.

These recommendations for Vitamin A are part of a broader review that includes other vitamins, essential minerals, and trace elements, reflecting the latest research in nutrient bioavailability and the role of different food components. Additionally, the publication serves as a critical resource for nutrition professionals, pinpointing current knowledge gaps in the health implications of these micronutrients.

References:


  1. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc


Upload Whole Genome Sequencing (WGS) raw DNA data today and take a deep dive into your genome!

Or if you only have standard microarray data currently, upload raw DNA data to get started with your free DNA raw data analysis today!