White Kidney Bean Extract Overview

1) Conditions Studied

White Kidney Bean Extract has been primarily studied for its potential impact on weight loss and blood sugar control. It's also been researched for its effects on obesity, diabetes, and metabolic syndrome.

2) Efficacy in Treating Conditions

Research provides mixed results on the efficacy of White Kidney Bean Extract. Some studies suggest that it can inhibit the enzyme alpha-amylase, which may reduce the absorption of carbohydrates and aid in weight loss. However, more extensive and long-term clinical trials are necessary to confirm these effects and the extent to which it may benefit those conditions.

3) Health Benefits

• Weight Management: May help in reducing the absorption of carbohydrates, potentially leading to weight loss.
• Blood Sugar Control: Could assist in managing blood sugar levels by slowing down the digestion of carbohydrates.
• Appetite Control: Some users report reduced appetite, which can contribute to weight loss efforts.

4) Downsides

• Gastrointestinal Issues: Some individuals may experience bloating, gas, or diarrhea.
• Limited Research: There is a lack of long-term studies to fully understand the potential adverse effects and safety profile.
• Interference with Medications: It may interact with diabetes medications and other dietary supplements.

5) Genetic Variations and Impact

There's limited research on the interaction between White Kidney Bean Extract and specific genetic variations. Individual responses to the extract can vary widely, and it is possible that certain genetic factors could influence the effectiveness or risk of side effects. However, more targeted studies are needed to identify any particular genetic variations that would significantly benefit or be harmed by the use of this supplement.

White Kidney Bean Extract Research Summary

Effects on Obesity and Diabetes

A series of studies have investigated the impacts of White Kidney Bean Extract and its components on obesity and diabetes. Notably, the extract contains an amylase inhibitor which is shown to reduce absorption of carbohydrates, potentially aiding in weight loss and improving carbohydrate metabolism in non-insulin-dependent diabetics.

Key Findings:

• White Kidney Bean Extract led to reduced body fat in obese Zucker rats without muscle protein loss, especially in low-fat diets.
• The extract lowered plasma insulin levels in obese rats, signifying potential benefits in managing obesity.
• Ingestion of the amylase inhibitor from the extract significantly reduced post-meal blood glucose and insulin levels in diabetics and healthy individuals.
• A clinical trial with Phase 2, a proprietary white bean extract, showed a trend towards weight loss and reduced triglyceride levels in obese adults, although not statistically significant.

Considerations and Conclusions

While White Kidney Bean Extract has demonstrated promising effects on obesity and diabetes management, the studies also highlight the need for careful consideration regarding dosage and potential protein loss in lean individuals. The clinical trial for Phase 2 suggests the potential for treatment but emphasizes the need for further research to confirm effectiveness.

References:

1. Lipid accumulation in obese Zucker rats is reduced by inclusion of raw kidney bean (Phaseolus vulgaris) in the diet
2. Gastrointestinal and metabolic effects of amylase inhibition in diabetics
3. Consumption of black beans and navy beans (Phaseolus vulgaris) reduced azoxymethane-induced colon cancer in rats
4. Starch blockers: a potential source of trypsin inhibitors and lectins
5. Effects of decreasing intraluminal amylase activity on starch digestion and postprandial gastrointestinal function in humans
6. Effect of a purified amylase inhibitor on carbohydrate tolerance in normal subjects and patients with diabetes mellitus
7. Insecticidal activity of an alpha-amylase inhibitor-like protein resembling a putative precursor of alpha-amylase inhibitor in the common bean, Phaseolus vulgaris L
8. Partially purified white bean amylase inhibitor reduces starch digestion in vitro and inactivates intraduodenal amylase in humans
9. Blocking carbohydrate absorption and weight loss: a clinical trial using Phase 2 brand proprietary fractionated white bean extract

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