Gene ADM
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Also known as
AM, PAMPOverview
The ADM gene encodes the adrenomedullin (ADM), a 52-amino acid peptide hormone that is widely distributed in the body, including the heart, blood vessels, and lungs. ADM has potent vasodilator and hypotensive effects and is involved in the regulation of blood pressure, fluid balance, and cardiovascular homeostasis. It also plays a role in the regulation of smooth muscle cell proliferation and migration, and it has anti-inflammatory and anti-apoptotic effects. ADM levels are elevated in various cardiovascular and inflammatory disorders, such as hypertension, atherosclerosis, and sepsis. The ADM gene is located on chromosome 3 and has been studied as a potential therapeutic target for hypertension and other cardiovascular conditions.