Gene GNB3
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Also known as
CSNB1H, HG2DOverview
GNB3 (guanine nucleotide binding protein, beta 3) is a gene that codes for the guanine nucleotide-binding protein, beta-3 (GNB3) protein. GNB3 is a member of the G protein family, which are activated by various extracellular signals and play a key role in intracellular signaling pathways.
The GNB3 protein is a G protein subunit that is a part of the G protein-coupled receptor signaling system, which is involved in a wide range of physiological processes including cell growth, metabolism, and behavior. Specifically, GNB3 is associated with the G-protein G-alpha-q, which is activated by receptors for neurotransmitters such as acetylcholine, histamine and serotonin, and also by receptor for hormones such as thyrotropin-releasing hormone (TRH) and luteinizing hormone-releasing hormone (LHRH).
There is evidence that variations in the GNB3 gene, particularly a single nucleotide polymorphism (SNP) known as C825T, are associated with increased risk of hypertension and cardiovascular disease. Studies have also suggested that the GNB3 gene may be involved in the development of certain psychiatric conditions such as anxiety and depression. Additionally, the C825T SNP has been also associated with increased sensitivity to pain, and increased risk for substance abuse.