Gene IL15RA
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Also known as
interleukin 15 receptor subunit alpha, IL-15RA, CD215Overview
IL15RA (Interleukin 15 Receptor Subunit Alpha) encodes the alpha chain of the interleukin-15 receptor, which is essential for IL-15 signaling. IL-15 is crucial for the development, survival, and activation of natural killer (NK) cells and memory CD8+ T cells. Unlike most cytokine receptors, IL15RA presents IL-15 in trans to other cells, a unique mechanism called trans-presentation.Variants in IL15RA can affect NK cell and memory T cell function, influencing immune responses to viral infections and cancer surveillance. The gene has been associated with susceptibility to autoimmune conditions and response to certain immunotherapies. IL-15 signaling through IL15RA is also important for maintaining intestinal intraepithelial lymphocytes.
Understanding your IL15RA genetic status provides insights into NK cell function and adaptive immune memory. This information is relevant for understanding immune surveillance capacity, response to viral infections, and potentially autoimmune disease susceptibility.