Also known as
GTBP, GTMBP, HNPCC5, HSAP, LYNCH5, MMRCS3, MSH-6, p160
Overview
The MSH6 gene provides instructions for making a protein called mutS homolog 6. This protein is involved in the repair of mistakes that occur when DNA is copied during cell division. It is a member of a class of proteins called DNA mismatch repair proteins, which work together to recognize and correct errors in DNA sequence that could lead to genetic changes. The MSH6 protein plays a particularly important role in detecting and repairing mistakes involving base pairs that are adjacent to each other, known as short loops or "hairpins."
Mutations in the MSH6 gene can cause a type of inherited cancer called hereditary nonpolyposis colon cancer (HNPCC), also known as Lynch syndrome. HNPCC is characterized by a high risk of developing colon cancer and other types of cancer, such as uterine, ovarian, and stomach cancer. Individuals with HNPCC often have a family history of these cancers and may develop them at a younger age than is typical. Treatment for HNPCC often includes regular cancer screenings, such as colonoscopies, and may include surgery, chemotherapy, and other types of medical therapy.
NutraHacker Raw DNA Analysis Products that include this gene
Upload raw DNA data to get your very own analysis of gene MSH6 through your personalized Critical Genetics Basic Report.