Also known as
SLC6A2, NAT1, NET1, SLC6A5
Overview
NET (norepinephrine transporter) is a gene that codes for the NET protein, which is a member of the SLC6 family of neurotransmitter transporters. Neurotransmitter transporters are a group of proteins that are responsible for the reuptake of neurotransmitters, which are chemicals that transmit signals between nerve cells in the brain.
The NET protein is responsible for the reuptake of the neurotransmitter norepinephrine (also known as noradrenaline), which is a key player in the regulation of mood, attention, and the "fight or flight" response. NET is primarily found in the sympathetic nervous system, which is responsible for the body's response to stress and emergency situations.
The NET protein is also a target for certain drugs such as antidepressants (such as tricyclic antidepressants and selective norepinephrine reuptake inhibitors) and ADHD medications (such as atomoxetine and guanfacine) which works by inhibiting the activity of the NET protein, leading to increased levels of norepinephrine in the brain.
Variations in the NET gene have been associated with an increased risk of certain psychiatric and neurological disorders such as depression, anxiety, and attention deficit hyperactivity disorder (ADHD). Studies have suggested that the NET protein may be a potential therapeutic target for the development of new treatments for these disorders.
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