Gene SEC14L2
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Also known as
SEC14-like 2, SPF, TAPOverview
SEC14L2 (SEC14-like 2) encodes a member of the SEC14 protein family, which are lipid-binding proteins involved in intracellular lipid transport and metabolism. The SEC14L2 protein contains a SEC14 domain that can bind phosphatidylinositol and phosphatidylcholine, two important membrane phospholipids. This protein is thought to play a role in regulating lipid homeostasis, vesicular trafficking, and cell signaling pathways. SEC14L2 is expressed in various tissues and may be involved in processes related to cellular membrane dynamics and lipid metabolism.Genetic variants in SEC14L2 have been associated with serum lipid levels, particularly affecting vitamin E (alpha-tocopherol) concentrations in the blood. Some studies have found associations between SEC14L2 polymorphisms and metabolic traits including cholesterol metabolism and cardiovascular disease risk factors. The gene's role in lipid binding and transport suggests it may influence how the body processes and distributes fat-soluble vitamins and other lipophilic molecules. Understanding SEC14L2 genetic variation may provide insights into individual differences in lipid metabolism, vitamin E status, and potentially cardiovascular health outcomes.