Gene VEGF
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Also known as
Vascular endothelial growth factor, VEGFA, VPFOverview
VEGF (Vascular Endothelial Growth Factor), also known as VEGFA, is a potent signaling protein that promotes angiogenesis, the formation of new blood vessels from existing vasculature. VEGF is essential for embryonic development, wound healing, exercise adaptation, and tissue repair. It stimulates endothelial cell proliferation, migration, and survival, and also increases vascular permeability.Genetic variants in VEGF influence baseline VEGF production and response to hypoxia, exercise, and injury. Higher VEGF expression may enhance capillary density, improve oxygen delivery to tissues, and promote better exercise adaptation and recovery. This can be advantageous for endurance athletes and individuals recovering from injury. However, excessive VEGF signaling has also been implicated in pathological angiogenesis, including tumor growth and progression, diabetic retinopathy, and age-related macular degeneration.
In the context of skin health, VEGF plays important roles in wound healing, scar formation, and skin aging. It promotes the formation of new blood vessels during wound repair but can also contribute to abnormal scarring and spider veins. Understanding VEGF genetics can inform personalized approaches to skincare, anti-aging interventions, athletic training, and therapeutic angiogenesis strategies.