Li-Fraumeni syndrome (LFS) is a rare and inherited genetic condition that increases the risk of developing a variety of cancers, particularly at an early age. People with LFS have a high risk of developing cancers such as sarcomas, leukemia, brain tumors, breast cancer, and adrenocortical carcinoma. The risk of cancer in individuals with LFS is much higher compared to the general population. LFS is caused by mutations in the TP53 gene, which provides instructions for making a protein that helps regulate the cell cycle and prevent the formation of cancer. The diagnosis of LFS is usually made through genetic testing, medical history, and a physical exam. Management may include increased cancer surveillance, risk-reducing strategies, and prophylactic surgeries. Genetic counseling is also recommended for individuals with LFS and their families. Early diagnosis and management are important to prevent or minimize the effects of LFS.
NutraHacker examines the following gene related to Li-Fraumeni syndrome:
For more information about your own genetic profile as related to Li-Fraumeni syndrome, please check out our NutraHacker Critical Genetics Basic Report Description.
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